Rotating disc type multi-nozzle three-dimensional controlled forming system for complex organ precursor

Abstract

The invention relates to a rotating disc type multi-nozzle three-dimensional controlled forming system for a complex organ precursor, belonging to the technical field of tissue engineering. The system mainly comprises a box body, a bracket, a rotating disc type multi-nozzle jetting device, a forming chamber, a forming table, a three-dimensional moving mechanism, a refrigerating device, a control system and a data processing system, wherein the rotating disc type multi-nozzle jetting device comprises a rotating disc and nozzle assemblies, and the nozzle assemblies are uniformly and circumferentially distributed on the rotating disc. When a precursor of a complex organ, such as liver, heart, kidney and the like, is formed, by utilizing a low-temperature deposition manufacturing process theory, the forming chamber is firstly cooled, the motions of the three-dimensional moving mechanism and the rotation and the material jetting of the rotating disc type multi-nozzle jetting device are controlled by the control system, and the forming table does three-dimensional motions; different nozzle assemblies can be changed by the rotation of the rotating disc so as to extrude to form and accumulate matrix materials with different tissue scaffolds and cells on the forming table. The device adopts a rotating disc type multi-nozzle interactive forming mode and can realize the precise forming of various non-homogeneous materials with complex three-dimensional structures.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to the design of a three-dimensional controlled forming system of a complex organ precursor with a turntable type and multiple nozzles. Background technique [0002] Tissue engineering is a popular interdisciplinary subject at present. Its three major elements are cells, biomaterial scaffolds and growth factors. [0003] In terms of the forming process of porous scaffolds, the traditional forming processes include: fiber weaving method, fiber bonding method, thermally induced phase separation method, solution casting porogen leaching method, melting molding method and air pressure pore forming method, etc. These methods can all form two-dimensional or three-dimensional porous scaffolds. However, the scaffolds prepared by these processes have certain limitations, such as lack of stable structure, poor mechanical properties, or harmful chemical solvent residues. All th...

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Problems solved by technology

[0015] ①Several nozzles are arranged on a fixed platform, requiring the forming area of ​​the bracket to be the intersection of the areas covered by all nozzles, which brings inconvenience to the development of multi-nozzle forming devices and cannot meet the forming requirements for large-sized brackets;

[0016] ② For the method of arranging several nozzles on a fixed platform, the position parameters of each nozzle are different, so it will bring trouble to the programming control process of forming, and it will also cause some inconvenience to the mutual switching of nozzle components

[0017] The concepts related to multi-nozzle and forming process are mentioned in Chinese National Patent (Application No. 00124985.1) (Application No. 200510063378.7) (Application No. 200610011550.9) (Application No. 200410009787.4) (Application No. 01141863.X) (Application No. 02148654.9) , however, there is no specific specification for the structural design of the multi-nozzle

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