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Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine

A technology for pseudoephedrine and sustained-release preparations, which is applied in the field of medicine and achieves the effects of reducing the number of times of taking, small fluctuation and stable blood drug concentration

Active Publication Date: 2010-06-30
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology solves problems with traditional methods for delivering medicine through skin or mucous membranes by allowing it to slowly dissolve over time without causing any side effects on other parts of our bodies. It achieves these benefits while maintaining stability at physiological levels within an organism's circulatory system.

Problems solved by technology

This patented technical problem addressed in this patents describes how to develop a new combination formulation containing three active ingredients (the first being called pseudoprofen) followed by each component separately chosen based on their desired therapeutic results. Previous methods were either slow down or require complicated steps like extractions before administering them individually. Therefore, these techniques had limitations because they could lead to overuse syndromes related to inflammability and reduced immunity.

Method used

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  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine
  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine
  • Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Benoate 500g

[0022] Pseudoephedrine Hydrochloride 90g

[0023] Chlorpheniramine Maleate 4g

[0024] Hypromellose K4M 50g

[0025] Microcrystalline Cellulose 80g

[0026] 5% povidone K30 aqueous solution appropriate amount

[0027] Magnesium Stearate Appropriate amount

[0028] Opadry 15g

[0029] Appropriate amount of pure water

[0030]

[0031] Made into 1000 pieces (grains / bag)

[0032] Preparation method 1:

[0033] (1) Preparation of granules Hypromellose and microcrystalline cellulose were sieved separately and mixed evenly. Then add pseudoephedrine hydrochloride, chlorpheniramine maleate, and benolate in sequence, fully mix, and use 5% povidone K30 aqueous solution as the soft material of the binder system, 20 mesh sieves to make wet granules, dry at 50°C, and dry for 20 Mesh sieve whole grain, set aside.

[0034] (2) Preparation of coating liquid Add Opadry to pure water, and add ...

Embodiment 2

[0049] prescription:

[0050] Benoate 400g

[0051] Pseudoephedrine Hydrochloride 120g

[0052] Chlorpheniramine Maleate 4g

[0053] Hypromellose K100M 60g

[0054] Hypromellose E58 5g

[0055] Microcrystalline Cellulose 60g

[0056] 10% povidone K30 aqueous solution appropriate amount

[0057] Appropriate amount of stearic acid

[0058] Opadry 50g

[0059] Appropriate amount of water

[0060]

[0061] Made into 1000 pieces (grains / bag)

[0062] Preparation method 1:

[0063] (1) Preparation of granules: Hypromellose and microcrystalline cellulose are sieved respectively, fully mixed with equal increment method, then add pseudoephedrine hydrochloride, beinolate, and chlorpheniramine maleate in prescribed quantities 2g, make it mix evenly, use 10% copovidone K30 aqueous solution as binder to make soft material, make wet granules with 20 mesh sieve, dry at 60 ℃, granulate with 20 mesh sieve, set aside.

[0064] (2) Preparation...

Embodiment 3

[0081] prescription:

[0082] pseudoephedrine sulfate

120g

Chlorpheniramine Maleate

4.0g

Benoate

400g

blank core

120g

Hypromellose E5

10g

Surelease Solids

30g

[0083] pseudoephedrine sulfate

120g

Water Soluble Coating Powder

10g

Titanium dioxide

1g

stearic acid

5g

Povidone K 30

Appropriate amount

water

Appropriate amount

Absolute ethanol

Appropriate amount

[0084] Coating prescription:

[0085] Opadry

30g

water

Add to 1000ml

[0086] Made into 1000 grains (tablets)

[0087] Preparation:

[0088] (1) Pseudoephedrine Sulfate Sustained Release Pellets

[0089] 1, prepare 10% HPMC E5 aqueous solution, standby;

[0090] II. Take Surelease solids, add water, shake well and set aside;

[0091] III. Prepare a water-soluble coating solution containing 10% of water-soluble coatin...

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Abstract

The invention provides a compound preparation which can comprehensively overcome the symptom relative to cold and can slowly release all the active ingredients. The slow-release preparation of the invention not only can overcome the symptom relative to cold but also can perform the synergistic function of compound medicine. The three active ingredients of the slow-release preparation of the invention can be released and absorbed synchronously so as to acquire expected releasing action in human body. The preparation of the invention can be taken for two times per day, namely, can be taken for one time in morning and evening instead of taking four times per day in the past. The preparation of the invention is characterized by less taking times, slow release in body, stable blood concentration, small fluctuation, high bioavailability and high safety.

Description

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Claims

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Application Information

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Owner 北京科信聚润医药科技有限公司
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