Unlock instant, AI-driven research and patent intelligence for your innovation.

Invertose (fructose/glucose) medicinal composition microsphere injection

A technology of injections and compositions, applied in the field of medicine, can solve the problems of incomplete absorption of energy and low bioavailability, and achieve the effects of improving bioavailability, simple preparation process, and low cost

Inactive Publication Date: 2012-02-15
HAINAN LINGKANG PHARMA CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patents are invert sugar preparations prepared by conventional production processes, and their bioavailability is low, and the energy cannot be completely absorbed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Invertose (fructose/glucose) medicinal composition microsphere injection
  • Invertose (fructose/glucose) medicinal composition microsphere injection
  • Invertose (fructose/glucose) medicinal composition microsphere injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 invert sugar injection

[0049] prescription:

[0050] Glucose 6.25g

[0051] Fructose 6.25g

[0052] Albumin 18.75g

[0053] PEG600 5g

[0054] making process:

[0055] (1) Dissolve 6.25g of glucose, 18.75g of albumin and 5g of PEG600 in 300ml of water for injection, filter to obtain a clear solution;

[0056] (2) Put the solution into the spray dryer and adjust the spray conditions: the inlet temperature is 60°C, the outlet temperature is about 40°C, the nozzle size is 0.5mm, the spray flow rate is 8ml / min, the compressed air velocity is 10L / min, spray dry, Obtain white microspheres with uniform shape;

[0057] (3) Mix the obtained microspheres and 6.25 g of fructose evenly, and distribute them into containers under aseptic conditions to obtain invert sugar pharmaceutical composition microsphere injections.

Embodiment 2

[0059] The preparation of embodiment 2 invert sugar injections

[0060] prescription:

[0061] Glucose 6.25g

[0062] Fructose 6.25g

[0063] Albumin 50g

[0064] PEG600 12.5g

[0065] making process:

[0066] (1) Dissolve 6.25g of glucose, 50g of albumin and 12.5g of PEG600 in 500ml of water for injection, filter to obtain a clear solution;

[0067] (2) Put the solution into the spray dryer, adjust the spray conditions: the inlet temperature is 80°C, the outlet temperature is about 50°C, the size of the nozzle is 1mm, the spray flow rate is 15ml / min, the compressed air velocity is 18L / min, spray dry, and get White microspheres with uniform shape;

[0068] (3) Mix the obtained microspheres and 6.25 g of fructose evenly, and distribute them into containers under aseptic conditions to obtain invert sugar pharmaceutical composition microsphere injections.

Embodiment 3

[0070] The preparation of embodiment 3 inversion sugar injections

[0071] prescription:

[0072] Glucose 12.5g

[0073] Fructose 12.5g

[0074] Albumin 37.5g

[0075] PEG600 10g

[0076] making process:

[0077] (1) 12.5g of glucose, 37.5g of albumin and 10g of PEG600 were dissolved in 500ml of water for injection to obtain an aqueous phase;

[0078] (2) Put the solution into the spray dryer and adjust the spray conditions: the inlet temperature is 70°C, the outlet temperature is about 40°C, the nozzle size is 0.6mm, the spray flow rate is 12ml / min, the compressed air velocity is 14L / min, spray dry, Obtain white microspheres with uniform shape;

[0079] (3) Mix the obtained microspheres and 12.5 g of fructose evenly, and dispense them into containers under aseptic conditions to obtain invert sugar pharmaceutical composition microsphere injections.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an invertose (fructose / glucose) medicinal composition microsphere injection, which is characterized by comprising the following components in part by weight: 1 part of glucose, 1 part of fructose, 3 to 8 parts of albumin and 0.8 to 2 parts of PEG 600. Compared with the prior art, the prepared invertose (fructose / glucose) medicinal composition microsphere injection has the advantages that: the stability is good, the encapsulation rate is high and a preparation process is suitable for industrial production; and the glucose has the appropriate controlled-release effect that the release amount does not exceed 30 percent within 1 hour, the release amount is between 50 and 70 percent within 6 hours, the release amount is between 65 and 85 percent within 12 hours and the release amount is not less than 80 percent within 18 hours.

Description

technical field [0001] The invention relates to an invert sugar (fructose / glucose) pharmaceutical composition microsphere injection, which belongs to the technical field of medicine. Background technique [0002] Invert sugar is an equal mixture of glucose and fructose. Fructose and glucose are isomers of each other. Fructose has optical left-handedness, also known as levulose. Its pharmacological effects are basically the same as glucose. When glucose and fructose provide energy in the body It can be transformed into each other. Among them, the metabolism of fructose does not depend on the regulation of insulin, and its metabolism speed is faster than that of glucose. It can be metabolized into glycogen without insulin, which can effectively reduce blood sugar fluctuations; Glucose can cause large fluctuations in blood sugar levels. The compound preparation composed of fructose and glucose-invert sugar is less dependent on insulin to participate in metabolism, and its ener...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/7004A61K47/42A61P3/02
Inventor 陶灵刚
Owner HAINAN LINGKANG PHARMA CO LTD