Compound combined preparation for preventing osteoarticular pain and preparation method thereof

A bone and joint pain and compound technology, which is applied in the field of glucosamine medicine and health care products, can solve the problems of single efficacy and low absorption utilization rate, and achieve the effects of fast dissolution, high absorption utilization rate, and enhanced stability

Active Publication Date: 2010-09-08
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a compound combination preparation for preventing and treating bone and joint pain and its preparation method, which solves the problems of single product efficacy and low absorption and utilization rate in the existing glucosamine health food, and creatively screens and Determine the preparation with a specific composition, so that the stability of the product is enhanced, and it is more in line with the requirements of human medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Glucosamine 700g

[0027] Microcrystalline Cellulose 121g

[0028] Sodium carboxymethyl starch 45g

[0029] Polyvinylpyrrolidone 35g

[0030] Tartaric acid 0.28g

[0031] Magnesium Stearate 12g

[0032] Appropriate amount of water

[0033] Appropriate amount of methanol

[0034] Titanium dioxide 32g

[0035] Prepare as follows:

[0036] 1) Mix a part of polyvinylpyrrolidone and tartaric acid, and prepare a 10% adhesive solution with a mixed solvent of an appropriate amount of methanol and water, and fully dissolve until clear and transparent;

[0037] 2) Pulverize the glucosamine and pass through a 120-mesh sieve;

[0038] 3) Put the glucosamine and the remaining dry polyvinylpyrrolidone powder into the wet granulator, stir for 5 minutes, and mix well;

[0039] 4) Add an appropriate amount of methanol and stir for 3 minutes, and let stand for 10 minutes;

[0040] 5) Evenly and slowly add the solution of the binder prepared in step 1, add liquid while stirring an...

Embodiment 2

[0044] Glucosamine 700g

[0045] Chondroitin Sulfate 350g

[0046] Collagen 150g

[0047] Microcrystalline Cellulose 121g

[0048] Sodium carboxymethyl starch 45g

[0049] Polyvinylpyrrolidone 35g

[0050] Tartaric acid 0.28g

[0051] Magnesium Stearate 12g

[0052] Appropriate amount of water

[0053] Appropriate amount of methanol

[0054] Polyethylene glycol 32g

[0055] Prepare as follows:

[0056] 1) Mix a part of polyvinylpyrrolidone and tartaric acid, and prepare a 10% adhesive solution with a mixed solvent of an appropriate amount of methanol and water, and fully dissolve until clear and transparent;

[0057] 2) Pulverize the glucosamine and pass through a 120-mesh sieve;

[0058] 3) Put the glucosamine and the remaining dry polyvinylpyrrolidone powder into the wet granulator, stir for 5 minutes, and mix well;

[0059] 4) Add an appropriate amount of methanol and stir for 3 minutes, and let stand for 10 minutes;

[0060] 5) Evenly and slowly add the solutio...

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PUM

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Abstract

The invention discloses a compound combined preparation for preventing osteoarticular pain and a preparation method thereof; the preparation comprises an active component glucosamine or combinations of more than one or two of the glucosamine and other active components chondroitin sulfate, dimethyl sulfoxide and collagen protein, and the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture thereof; and auxiliary materials comprise excipient, disintegration agent, lubricant, adhesive, stabilizer and wetting agent. The invention has good curing and preventing functions to injury in arthritis and joint movement, the prepared tablets have the advantages of good disintegration performance, high dissolution speed and quick effect, the used amount of the raw materials and all the auxiliary materials reaches the best ratio, the product stability is improved, and the absorption utilization rate is high.

Description

technical field [0001] The invention belongs to the technical field of glucosamine medicine and health products, and in particular relates to a compound combination preparation for preventing and treating bone and joint pain and a preparation method thereof. Background technique [0002] Osteoarthritis is a common chronic arthritis, and people have been looking for and exploring drugs for the development of osteoarthritis for many years. For a long time, people have used aspirin, non-steroidal analgesics, etc. to help patients relieve pain. These medicines are used for a long time, and some effects gradually decrease, and some produce side effects such as bloating and stomach pain. Arthritis is mainly the degeneration of articular cartilage and secondary hyperosteogeny. Because the mucous membrane at the joint joint is composed of sulfur-containing protein and glucosamine. Sulfur-containing proteins such as collagen and glucosamine can promote the production of collagen, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/737A61K31/10A61K38/39A61K9/28A61P19/02A61P29/00
Inventor 王乔飞卢鹏飞张涛张国栋边立峰夏旭东
Owner JIANGSU ALAND NOURISHMENT
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