Oxcarbazepine-containing oral dispersing membrane and preparation method thereof

A technology of dispersing film and oral cavity, which is applied in the field of pharmaceutical preparations, can solve the problems of patients' strong psychological suggestion of medication, unfavorable medication privacy, and the impact of treatment effects, etc., and achieve the effect of good taste, convenient medication, and easy acceptance

Inactive Publication Date: 2018-12-18
SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The administration process of the above dosage forms will give patients a strong psychological hint of medication, and it is not conducive to the privacy of medication, which will have a certain impact on the therapeutic effect.
At present, there is no relevant report on making oxcarbazepine into oral film

Method used

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  • Oxcarbazepine-containing oral dispersing membrane and preparation method thereof
  • Oxcarbazepine-containing oral dispersing membrane and preparation method thereof
  • Oxcarbazepine-containing oral dispersing membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Influence of API Particle Size on Product Quality

[0049]

[0050] The appearance of the film preparation prepared by the above components is light yellow, complete and smooth, uniform in thickness, the breaking force is in the range of 15-25N, and the toughness is good, which meets the requirements of production, transportation and use. The disintegration time limit is within 15-30 seconds.

Embodiment 2

[0052] Influence of dosage of API and film-forming agent on product quality

[0053]

[0054] The appearance of the film preparation prepared by the above components is light yellow, complete and smooth, uniform in thickness, the tensile force is in the range of 16-28N, and the toughness is good, which meets the requirements of production, transportation and use. The disintegration time limits are all within 25-40 seconds.

Embodiment 3

[0056] Influence of other material proportions on product quality

[0057]

[0058] The appearance of the film preparation prepared by the above components is light yellow, complete and smooth, with uniform thickness, the tensile force is in the range of 12-34N, and the toughness is good, which meets the requirements of production, transportation and use. The disintegration time limits are all within 20-49 seconds.

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Abstract

The invention relates to an oxcarbazepine-containing oral dispersing membrane and a preparation method thereof. The purpose of the invention is to provide the oxcarbazepine-containing oral dispersingmembrane having the advantages of high drug loading capacity, rapidness in disintegration in the oral cavity, fastness in releasing of the drug, no water drinking, and easiness in taking, and the preparation method thereof The oxcarbazepine-containing oral dispersing membrane includes an active component oxcarbazepine, a polymeric film-forming material, a disintegrating agent and other pharmaceutically-acceptable auxiliary materials. The physical properties of the membrane are ensured, the drug loading capacity is increased, and the rapid release of the drug is promoted.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oral film whose active ingredient is oxcarbazepine, and a preparation method of the preparation. Background technique [0002] Epilepsy is a common disease of the nervous system. It is a chronic brain disorder caused by a variety of reasons. It is usually characterized by abnormal high-frequency discharge of neurons in local lesions of the brain tissue, which spreads to the surroundings, resulting in temporary brain dysfunction. Can be divided into localized seizures and generalized seizures. More than half of the patients with epilepsy have onset in childhood. At present, drug treatment is the most important means of epilepsy treatment. The commonly used clinical drugs include phenytoin, diazepam, sodium valproate and carbamazepine, first-line antiepileptic drugs It can control epileptic seizures in about 70% of patients. [0003] Oxcarbazepine is slightly soluble i...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/36A61K47/20A61K31/55A61P25/08
CPCA61K9/006A61K9/7007A61K31/55A61K47/20A61K47/36A61K47/38A61P25/08
Inventor 王利民李树英吴学萍刘长涛王文笙景亚军
Owner SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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