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Method for purifying dihydromyricetin

A technique of dihydromyricetin and a purification method, which is applied in the field of separation of active components of natural products, can solve problems such as high equipment requirements, large solvent consumption, and low-temperature aging, and achieve simple equipment, large single-time processing capacity, and low cost. low effect

Inactive Publication Date: 2011-12-14
HANSHAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method consumes a lot of solvent, requires low-temperature aging, and requires high equipment

Method used

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  • Method for purifying dihydromyricetin

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Embodiment Construction

[0025] The present invention will be described in detail below through examples.

[0026] Weigh 10 g of dihydromyricetin crude product (48%, quantitatively analyzed by HPLC), add 20 ml of absolute ethanol, stir into a paste, add 10 g of activated carbon, and place at 60 ° C for 30 min; add 1200 ml of 90 ° C water, stir for a while After hot filtration, the filtrate was placed at room temperature overnight; after filtration and drying, dihydromyricetin crystals were obtained, weighing 4.28 g, with a purity of 83%.

[0027] The above obtained dihydromyricetin crystals are recrystallized according to the above operations. In the recrystallization, except that the addition of absolute ethanol is 8.5ml, the amount of activated carbon is 4.28g, and the amount of hot water is 513ml, the rest remain unchanged. The dihydromyricetin obtained by secondary crystallization Myricetin crystal 2.5g, purity 95%.

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Abstract

The invention discloses a method for purifying dihydromyricetin, which comprises the following steps of: (1) dissolving coarse dihydromyricetin in a certain amount of solvent, and blending into a paste; (2) uniformly mixing the paste and a certain amount of adsorbent, and drying at the temperature of between 45 and 75 DEG C for 0.25 to 1 hour; (3) placing the mixture in a certain amount of water,filtering while hot, and standing the filter liquor over night; (4) filtering and drying to obtain dihydromyricetin crystal; and (5) repeating the operation once according to the steps (1) to (4) on raw materials with the coarse product content of less than 50 percent, wherein the solid liquid mass ratio, the adsorbent amount and the hot water amount for the second time are in the standard ratio based on the mass of the dihydromyricetin crystal, the rest indexes are invariable. The method for purifying the dihydromyricetin has the advantages of greatly reduction of the solvent consumption, nosolvent loss, no operation such as heating the dissolved coarse products, distilling and recovering the solvent and the like, simple equipment, low input, energy conservation and environmental protection, fewer steps, high single processing capacity, low cost, and easy industrialized production in rural areas and farms.

Description

technical field [0001] The method relates to a method for purifying dihydromyricetin, and specifically involves using extracts of plants of the genus Vitis genus Vitaceae (such as vine tea, Cantonese snake grape, Big-leaf snake grape, and Odontodon grape) as raw materials, A method of purifying dihydromyricetin. It belongs to the field of separation of effective components of natural products. Background technique [0002] Dihydromyricetin (3,5,7,3',4',5'-hexahydroxy-2,3-dihydroflavonol, Dihydromyricetin) is a polyhydroxy dihydroflavonol. Since this compound exists in a large amount in the Vitaceae plants, such as Snake Grape, Yue Snake Grape, Snake Grape, Northeast Snake Grape, Snake Grape, etc., especially in the young stems and leaves of Snake Grape Its content can reach more than 30%, so this compound is also called staphylophyllin, as shown in the figure below. [0003] [0004] Modern medical research shows that, in addition to the common properties of flavonoids...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C07D311/40
Inventor 严赞开
Owner HANSHAN NORMAL UNIV
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