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Fructose diphosphate sodium tablet

A technology of sodium diphosphate tablet and sodium fructose diphosphate, which is applied in the directions of pill delivery, medical preparations of inactive ingredients, cardiovascular system diseases, etc., can solve the problems of low dissolution rate of sodium fructose diphosphate tablet, etc. Excellent compressibility and fluidity, smooth and beautiful sheet shape, and stable properties

Inactive Publication Date: 2010-09-15
张家港市华天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The invention provides a sodium fructose diphosphate tablet, and the purpose is to solve the problem of low dissolution rate of the existing sodium fructose diphosphate tablet

Method used

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  • Fructose diphosphate sodium tablet
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Examples

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Embodiment 1

[0038] Embodiment one: a kind of sodium fructose diphosphate tablet

[0039] The raw material formula of embodiment one, comparative example 1 and comparative example 2 is as shown in table 1

[0040] The preparation process of sodium fructose diphosphate tablet is as follows:

[0041] The first step: take sodium fructose diphosphate, sieve; take microcrystalline cellulose, lactose, sodium carboxymethyl starch, dry at constant temperature, crush and sieve; sieve magnesium stearate; use povidone to make a solution for binding agent.

[0042] Second step: take by weighing prescription quantity microcrystalline cellulose, lactose, sodium fructose diphosphate according to the principle of equal increase (get a small amount of components and an equal amount of large components, and mix uniformly in the mixing machine simultaneously, then Add the same amount of the same amount of the mixture and mix evenly, and increase the amount until all the large amount of components are added...

Embodiment 2 7

[0060] Embodiment 2~7: a kind of sodium fructose diphosphate tablet

[0061] Examples 2-7 Prepare sodium fructose diphosphate tablets with a specification of 250 mg, and the raw material formula is shown in Table 2.

[0062] The preparation technology of sodium fructose diphosphate tablet is the same as embodiment one:

[0063] Table 2

[0064]

[0065] When the mass ratio of the main ingredient (sodium fructose diphosphate) to the filler is greater than 1:0.29, the dissolution rate can only be less than or equal to 75%.

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Abstract

The invention relates to a fructose diphosphate sodium tablet mainly comprising the following raw materials in a formula: 78-88% of fructose diphosphate sodium, 2-16% of lactose, 1-6% of microcrystalline cellulose, 1-7% of carboxymethyl starch sodium and 1-3% of povidone. The dissolution of the prepared fructose diphosphate sodium tablet is greater than 90% within 30 minutes.

Description

technical field [0001] The invention relates to a sodium fructose diphosphate tablet, which belongs to the dosage form preparation technology of sodium fructose diphosphate medicament. Background technique [0002] Fructose-1,6-Diphosphate sodium (FDP) is a cell metabolite present in the human body, which can regulate the activity of various enzymes in glucose metabolism, improve the state of cellular hypoxia and ischemia, and is beneficial to Recovery of damaged hepatocytes. [0003] Sodium fructose diphosphate has been widely used clinically for the treatment of myocardial ischemia, shock, hypoxia, and tissue damage. The oral dosage form of sodium fructose diphosphate is mainly tablet, and the main component of existing sodium fructose diphosphate tablet is: sodium fructose diphosphate (crude drug), pregelatinized starch and microcrystalline cellulose (filler), starch ( disintegrant) and starch paste or cellulose-based mucilage (adhesive), which has a low dissolution rat...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7024A61K47/36A61K47/26A61K47/32A61P9/10A61P9/00A61P43/00
Inventor 刘士华
Owner 张家港市华天药业有限公司
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