Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Film coating agent for vitamin medicaments and preparation method thereof

A film coating agent and vitamin technology, which is applied in the directions of drug delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of insignificant oxygen barrier effect, decreased drug quality, and poor protection effect, etc. Good compatibility, complete and tough film formation, and the effect of improving product stability

Active Publication Date: 2012-11-14
TIANJIN BOKELIN MEDICINE PACKAGING TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when used on vitamin drugs, the protective effect after coating is not good, and the drug oxidation is prone to occur, so discoloration and mottled phenomena on the surface of the tablet are common, resulting in a decline in the quality of the drug
In many research literatures, adding hydrophobic ingredients such as acrylic resin to the coating formula has a good moisture-proof effect, but the barrier effect on oxygen is not obvious

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of film coating agent that is used for vitamin medicine, its component and the weight of each component are:

[0034] 60 grams of hydroxypropyl methylcellulose;

[0035] Polyethylene glycol 20 grams;

[0036] Gum Arabic 20 grams.

[0037] The steps of the above-mentioned production method for the film coating agent of vitamin medicine are:

[0038] (1) Take by weighing 60 grams of hydroxypropyl methylcellulose, 20 grams of polyethylene glycol, and 20 grams of gum arabic;

[0039] (2) Add the weighed hydroxypropyl methylcellulose, polyethylene glycol, and gum arabic into a high-speed shearing machine, and mix the materials evenly at a speed of 350 rpm to obtain the finished coating agent. High efficiency and low energy consumption.

[0040] In this embodiment, no coloring agent is used, a transparent film can be formed, and the original appearance characteristics of the product can be reflected.

[0041] Recipe 3

Embodiment 2

[0043] A kind of film coating agent that is used for vitamin medicine, its component and the weight of each component are:

[0044] 30 grams of hydroxypropyl methylcellulose;

[0045] Polyethylene glycol 18 grams;

[0046] Gum Arabic 30 grams;

[0047] Titanium dioxide 22 grams.

[0048] The steps of the above-mentioned production method for the film coating agent of vitamin medicine are:

[0049] (1) Take by weighing 30 grams of hydroxypropyl methylcellulose, 18 grams of polyethylene glycol, 30 grams of gum arabic, and 22 grams of titanium dioxide;

[0050] (2) Add the weighed hydroxypropyl methylcellulose, plasticizer polyethylene glycol, gum arabic, and titanium dioxide into the high-speed shearing machine, and mix the materials evenly at a speed of 500 rpm;

[0051] (3) Increase the speed of the high-speed shearing machine to 900 rpm, the particle size of the titanium dioxide is 10-20 μm, the colorant is fully dispersed, and a finished coating agent with uniform color ...

Embodiment 3

[0054] A kind of film coating agent that is used for vitamin medicine, its component and the weight of each component are:

[0055] 45 grams of hydroxypropyl methylcellulose;

[0056] Glycerin 10 grams;

[0057] Gum Arabic 20 grams;

[0058] 25 grams of color lake.

[0059] The steps of the above-mentioned production method for the film coating agent of vitamin medicine are:

[0060] (1) Take by weighing 45 grams of hydroxypropyl methylcellulose, 10 grams of glycerin, 20 grams of gum arabic, and 25 grams of color lake;

[0061] (2) The hydroxypropyl methylcellulose, polyethylene glycol, gum arabic, and color lake that are weighed are added in the high-speed shearing machine, and the material is mixed evenly with the speed of 500 revs / min;

[0062] (3) The speed of the high-speed shearing machine is increased to 1000 rpm, the particle size of the color lake is 1-10 μm, the colorant is fully dispersed, and a finished coating agent with uniform color is obtained.

[0063] Re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a film coating agent for vitamin medicaments, which comprises the following components in parts by weight: 30-60 parts of hydroxypropyl methyl cellulose, 5-30 parts of plasticizer and 2-30 parts of Arabic gum. The invention also relates to a production method of the film coating agent for the vitamin medicaments, which comprises the following steps of: (1) weighing the hydroxypropyl methyl cellulose, the plasticizer and the Arabic gum by weight parts; and (2) adding the hydroxypropyl methyl cellulose, the plasticizer and the Arabic gum into a high-speed shearing machine and uniformly mixing the materials at the speed of 350-600 rpm to prepare a finished coating agent product. The coating agent has safety and no toxicity; the formed coating film has favorable blocking function on gases, such as oxygen, and the like, plays a favorable protection role for the vitamin medicaments which are easy to oxidize, prevents oxidization and discoloration of the vitamin medicaments and improves the stability of the product; and the preparation method of the coating agent has the outstanding advantages of high production efficiency, low energy consumption, favorable application performance of the finished coating agent product, and the like.

Description

technical field [0001] The invention belongs to the field of coating agents, in particular to a film coating agent for vitamin drugs and a preparation method thereof. Background technique [0002] Vitamins are essential nutrients for human beings, and have the functions of anti-aging, preventing heart disease and anti-cancer. In recent years, many brands of multivitamin tablets have entered the market. They have the characteristics of comprehensive supplementation, convenient taking, and adaptability to people with different physiques. They have become an effective way for people to improve their physical fitness and resistance. [0003] However, vitamin components are unstable, for example, the structure of vitamin A contains more unsaturated double bonds, which is easy to oxidize and has poor stability; the molecule of vitamin C has a dienol structure, which is prone to various degradation reactions, so vitamin tablets ( Especially multivitamin drugs) after long-term stor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/36
Inventor 赵永建邵广川王磊
Owner TIANJIN BOKELIN MEDICINE PACKAGING TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com