Comprehensive genetic analysis method of susceptibility of complex diseases

A genetic analysis method and susceptibility technology, applied in the field of comprehensive genetic analysis of complex disease susceptibility, can solve the problems of high certainty, lack of effective integration and evaluation system, and time-consuming, and achieve the effect of improving certainty

Inactive Publication Date: 2010-09-29
孟涛 +1
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Problems solved by technology

At present, the genetic analysis of complex diseases by calculating the CGR value has not been reported in my country.
[0005] 2. Although there are many research results on finding susceptibility genes and SNP sites related to complex diseases, due to the obvious differences in SNP sites between races or groups and the types and effects of other risk factors related to diseases of various races or groups The intensity is also different. Therefore, genetic testing and genetic analysis for complex diseases of the Chinese Han must be based on the proprietary data of the Chinese Han. Lack of effective integration and evaluation system for SNP sites
[0006] 3. The CGR calculation process is cumbersome and time-consuming, and the genetic analysis takes a long time, which cannot well meet the cus

Method used

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Embodiment Construction

[0020] Concrete steps of the present invention are as follows:

[0021] 1) Establish a genetic database related to complex diseases and determine relevant detection sites. The present invention introduces the concept of "evidence-based", classifies and evaluates disease-related genetic data (mainly based on indicators such as research type, sample size, and whether there are Han Chinese research data), and screens out complex diseases for Chinese Han people who are prone to diseases. Sensitive gene detection SNP loci to improve the certainty of predicting the susceptibility of complex diseases in the Chinese Han population.

[0022] 2) Using Affymetrix6.0 chip technology to genotype the SNPs loci in the whole genome of the individual, and obtain the genotype corresponding to each SNP locus.

[0023] 3) From the detection results of 900,000 SNP sites on the 6.0 chip, derive the genotyping results of the disease-related SNP sites we determined, based on the genotyping results, ...

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Abstract

The invention relates to a comprehensive genetic analysis method of susceptibility of complex diseases, which comprises the following steps: 1) establishing related genetic databases of complex diseases and determining related detection sites; 2) carrying out genotyping for SNPs sites within individual whole genome by using the Affymetrix6.0 chip technology to obtain the corresponding genotype of each SNP site; 3) exporting determined disease-related SNP site typing results from 900,000 SNP site detection results of a 6.0 chip, and calculating a CGR value according to the genotyping results; and 4) carrying out particular and deep genetic analysis for increased-risk diseases and high-risk diseases according to the calculated disease-related CGR value. The invention can improve the certainty of the susceptibility predication of complex diseases of Chinese Han population, shortens genetic analysis time and prevents calculation errors caused by manual calculation.

Description

technical field [0001] The invention relates to a method for comprehensive genetic analysis of complex disease susceptibility. Background technique [0002] Complex diseases, such as hypertension, coronary heart disease, etc., have high morbidity and mortality, and have become the main reason affecting the overall health level of our country, and also an important factor restricting the social and economic development of our country. Genetic detection of complex disease-related genes and mutation sites can assess the susceptibility of diseases early and take corresponding preventive measures to reduce the incidence of diseases. A large number of studies have confirmed that genetic factors play an important role in the susceptibility of diseases. The genetic factors of complex diseases have confirmed the existence of minor gene dosage effects, that is, the accumulation of minor gene effects can form a significant phenotypic comprehensive effect. Therefore, for many The detec...

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Application Information

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IPC IPC(8): C12Q1/68G06F19/00
Inventor 杨进孟涛
Owner 孟涛
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