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Injection with vitexin-2''-O-rhamnoside as raw material and preparation method thereof

A technology of rhamnoside and vitexin, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of low bioavailability and affecting drug absorption, etc., and achieve broad market prospects and good curative effect Effect

Inactive Publication Date: 2010-10-06
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Some data show that after oral administration of flavonoid glycosides, the chemical components interact with intestinal flora to affect drug absorption, and the bioavailability is low

Method used

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  • Injection with vitexin-2''-O-rhamnoside as raw material and preparation method thereof
  • Injection with vitexin-2''-O-rhamnoside as raw material and preparation method thereof
  • Injection with vitexin-2''-O-rhamnoside as raw material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The injection with vitexin-2″-O-rhamnoside as raw material is prepared by adding 15 g of vitexin-2″-O-rhamnoside to 1000 ml of water for injection, and it is packaged in 500 vials.

[0016] The preparation technology of above-mentioned injection is:

[0017] Take vitexin-2″-O-rhamnoside for injection and water for injection, the weight ratio of vitexin-2″-O-rhamnoside to water is 10:1000, to vitexin-2″-O -Rhamnoside was dissolved by adding about half of the prepared amount of water for injection, then added water for injection to the full amount, stirred evenly, pre-filtered, sterilized and filtered through a 0.22μm microporous membrane, and then filtered at the end, under the protection of sterile nitrogen Under aseptic filling, that is.

Embodiment 2

[0019] The injection with vitexin-2″-O-rhamnoside as raw material is prepared by adding 10 g of vitexin-2″-O-rhamnoside to 1000 ml of water for injection, and it is divided into 100 bottles.

[0020] The preparation method of the injection with vitexin-2″-O-rhamnoside as raw material is to take 1000ml of water for injection at a temperature of 20±1°C, inject clean carbon dioxide gas into the liquid for about 15 minutes, add vitexin-2 ″-O-rhamnoside, stir well. The solution continued to pass through clean carbon dioxide gas for about 5 minutes, and then was sterilized and filtered through a 0.22 μm microporous membrane, and then distributed into 5-15ml special glass vials for freeze-dried powder injection. Pre-freeze for 4 hours, then freeze-dry for 36 hours, press the cap, and tie the aluminum cap.

Embodiment 3

[0022] The injection with vitexin-2″-O-rhamnoside as raw material is prepared by adding 10 g of vitexin-2″-O-rhamnoside to 1000 ml of water for injection, and it is divided into 200 bottles.

[0023] The preparation method of the injection with vitexin-2″-O-rhamnoside as raw material is to take 1000ml of water for injection at a temperature of 20±1°C, inject clean nitrogen into the liquid for about 30 minutes, and add vitexin-2″ -O-rhamnoside, stir well. The solution continued to pass through clean nitrogen for about 10 minutes, and then was sterilized and filtered through a 0.22 μm microporous membrane, and then distributed into 5-15ml special glass vials for freeze-dried powder injection. Pre-freeze for 4 hours, then freeze-dry for 36 hours, press the cap, and tie the aluminum cap.

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Abstract

The invention discloses injection with vitexin-2''-O-rhamnoside as a raw material and a preparation method thereof. The preparation method is characterized by comprising the following steps of: weighing the vitexin-2''-O-rhamnoside for injection and water for injection in a weight ratio of 2:1,000-20:1,000; adding the water for injection in an amount which is about half the weight of the vitexin-2''-O-rhamnoside into the vitexin-2''-O-rhamnoside to dissolve the vitexin-2''-O-rhamnoside; then adding the rest amount of the water for injection into the mixture; stirring the mixture uniformly and pre-filtering the mixture; sterilizing and filtering the mixture by a microfiltration membrane of 0.22 micron; and aseptically encapsulating the mixture under the protection of aseptic nitrogen to obtain the injection. The injection with vitexin-2''-O-rhamnoside as the raw material can be individually or cooperatively applied to the treatment of chest stuffiness and pain with good therapeutic effect.

Description

technical field [0001] The present invention relates to vitexin-2″-O-rhamnoside injection, in particular to the preparation of an injection for treating chest pain and heartache by taking vitexin-2″-O-rhamnoside, an active monomer component of hawthorn leaves, as a pharmaceutical component method. Background technique [0002] According to the statistical data of the Ministry of Health, in recent years, the death toll of cardiovascular disease has accounted for more than one-third of the total death toll in our country, ranking first among the top ten causes of death of urban and rural population. The morbidity, disability and mortality of cardiovascular diseases are increasing year by year. In view of the harmfulness of cardiovascular diseases, the World Health Organization has listed it as one of the current overall priorities of the organization. Chronic diseases represented by cardiovascular diseases have become an important problem that seriously threatens human health...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/08A61K9/19A61P9/08A61P9/00
Inventor 英锡相康廷国张文洁杜洋程忠哲
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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