Preparation of 6-oxa-8alpha-steroid estrogen analogues - a new group of unnatural estrogens and their use in medicine

A technology for steroidal estrogens and analogs, applied in the field of novel 6-oxa-8α-steroidal estrogen analogs, can solve the problems of increasing the risk of uterine cancer and endometrial cancer, and use restrictions
CN101855234AInactive Publication Date: 2010-10-06TOPASS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TOPASS
Publication Date
2010-10-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention is related to the area of new 6-Oxa-8a-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8a-steroid estrogens and their use as estrogen receptor modulators. These new estrogen analogues are ligands for estrogen receptors and as such may be useful for the treatment and prevention of a variety of conditions related to estrogen functioning. These conditions include bone and cartilage disorders, increased levels of LDL cholesterol, cardiovascular diseases, impairment of cognitive function, cerebral degeneration disorders, endometriosis and other types of inflammation, the metabolic syndrome, and cancer, in particular of the breast, uterus and prostate.
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Description

technical field

[0001] The present invention relates to a novel 6-oxa-8α-steroidal estrogen analog and a method for synthesizing these biologically active novel steroidal estrogen analogues, that is, the synthesis of 6-oxa-8α-steroidal estrogen Technical field of preparation methods and their use as receptor modulators. These novel estrogen analogs are ligands for the estrogen receptor and thus are useful in the treatment and prevention of conditions associated with estrogen functioning. These conditions include bone and cartilage disease, elevated LDL cholesterol levels, cardiovascular disease, cognitive impairment, degenerative brain disease, endometriosis and other types of inflammation, metabolic syndrome, and cancer, especially breast cancer cancer, uterus and prostate cancer. Background technique

[0002] Naturally occurring and synthetic estrogens are used in a wide range of treatments, including relief of menopausal syndrome, treatment of breast and prostate cancer...

Claims

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