Valsartan amlodipine capsule medicine compound and preparation method thereof

A kind of technology of valsartan amlodipine capsule and composition, which is applied in the field of medicine and can solve problems such as failure, delaying the time for blood pressure to reach the standard, patient frustration and the like

Active Publication Date: 2010-10-20
CHANGZHOU NO 4 PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The step-by-step treatment plan often used in clinical practice will delay the tim

Method used

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  • Valsartan amlodipine capsule medicine compound and preparation method thereof
  • Valsartan amlodipine capsule medicine compound and preparation method thereof
  • Valsartan amlodipine capsule medicine compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The formula for making 1000 capsules is as follows:

[0051]

[0052] The second part of the present invention relates to the preparation method of preparing valsartan amlodipine capsule composition, its step comprises

[0053] 1) Preparation and processing of raw and auxiliary materials: pass valsartan and amlodipine besylate through a 100-mesh sieve for subsequent use;

[0054] 2) Valsartan granules: take by weighing valsartan, microcrystalline cellulose pH102 and cross-linked polyvinylpyrrolidone of the prescribed amount, mix through a 100 mesh sieve, so that it is fully mixed, and use 2% hydroxypropyl methyl The cellulose aqueous solution is used as a wetting agent, granulated with a 30-mesh sieve, dried at a temperature of 50±5°C, and then granulated with a 30-mesh sieve to obtain valsartan granules;

[0055] 3) Amlodipine besylate granules: take the amlodipine besylate, microcrystalline cellulose pH102 and cross-linked polyvinylpyrrolidone of the prescribed am...

Embodiment 2

[0061] The formula for making 1000 capsules is as follows:

[0062]

[0063] The second part of the present invention relates to the preparation method of preparing valsartan amlodipine capsule composition, its step comprises

[0064] 1) Preparation and processing of raw and auxiliary materials: pass valsartan and amlodipine besylate through a 100-mesh sieve for subsequent use;

[0065] 2) Valsartan granules: take by weighing valsartan, microcrystalline cellulose pH102 and cross-linked polyvinylpyrrolidone of the prescribed amount, mix through a 100 mesh sieve, so that it is fully mixed, and use 2% hydroxypropyl methyl The cellulose aqueous solution is used as a wetting agent, granulated with a 30-mesh sieve, dried at a temperature of 50±5°C, and then granulated with a 30-mesh sieve to obtain valsartan granules;

[0066] 3) Amlodipine besylate granules: take the amlodipine besylate, microcrystalline cellulose pH102 and cross-linked polyvinylpyrrolidone of the prescribed am...

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PUM

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Abstract

The invention relates to a valsartan amlodipine capsule medicine compound and a preparation method thereof. The compound uses valsartan and amlodipine as raw materials, containing one or more medicinal excipient. The preparation method thereof comprises the step of respectively mixing the valsartan and amlodipine with selective thinner, adhesive, disintegrating agent, antitack agent and lubricant, adding a proper wetting agent to make into softwood, sieving for making into wet grain, drying the wet grain, sieving, mixing uniformly and making into orally taken preparation which has obvious effect for treating hypertension.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more precisely relates to a valsartan amlodipine capsule and a preparation method thereof. Background technique [0002] According to statistics, 1 / 4 of the world's population suffers from high blood pressure, but the control rate of blood pressure is not ideal, and patients often cannot reach the target recommended by the guidelines. WHO multi-country monitoring of cardiovascular disease incidence trends and determinants (MONICA study) confirmed that only 13% to 38% of males and 17% to 54% of female patients with hypertension between the ages of 35 and 64 received antihypertensive treatment However, many patients who received treatment did not reach the target, and the treatment target ratios of male and female patients were only 13%-67% and 12%-63%, respectively. Many patients require multiple antihypertensive drug regimens to achieve goals. [0003] The 2007 "European Society of Hyperte...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/41A61K9/48A61P9/12
Inventor 严洁黄欣王晓东屠永锐
Owner CHANGZHOU NO 4 PHARMA FACTORY
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