Valsartan compound and new manufacturing method thereof

Abstract

The invention provides a valsartan compound and a new manufacturing method thereof. In the invention, through specially designed methods for acid and alkali conversion and absorption by macroporous absorption resin, the aim of refining and purifying can be fulfilled; and thus, the high-purity valsartan compound is obtained, the product quality of the preparation is improved, the toxic and side effects are reduced, and the clinic medicine safety of the valsartan in the preparation of antihypertensive medicines is guaranteed.

Description

Valsartan compound and its new preparation method technical field The invention relates to a refining method of a valsartan compound, which can obtain high-purity valsartan, and belongs to the technical field of medicine. Background technique Valsartan, chemical name: N-(1-pentanoyl)-N-[4-[2-(1H-tetrazol-5-yl)phenyl]-L-valine, molecular formula : C24H29N5O3, molecular weight: 435.52, structural formula: Valsartan is an antihypertensive drug, white powder, odorless, tasteless, easily soluble in methanol, soluble in chloroform, almost insoluble in water, developed by Swiss Novartis, and launched in 1996. Angiotensin, the main active substance of the renin-angiotensin system, is a powerful vasoconstrictor polypeptide, and its biological functions are mainly reflected in the regulation of vascular tension, blood flow, promotion of cell growth, proliferation and inflammation . Valsartan is a non-peptide angiotensin (AT) II receptor antagonist, which can antagonize the s...

AI Technical Summary

Problems solved by technology

For these impure products, the prior art does not disclose the method for purifying valsartan. In fact, those skilled in the art with general experience clearly know that they face various difficulties in obtainin

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