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Process method for microwave assistant supercritical extraction of active ingredients of curcuma

A technology of supercritical extraction and active ingredients, which is applied in the direction of medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, pharmaceutical formulas, etc., which can solve the imbalance of extract components, low efficiency of steam method, Solve problems such as organic solvent residues, and achieve the effect of integrated extraction with high efficiency, low cost, and prevention of pyrolysis

Inactive Publication Date: 2011-06-22
GUANGZHOU RZN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The extraction method of turmeric is generally based on solvent extraction and water vapor extraction, but the above-mentioned methods all have shortcomings in varying degrees: for example, the product of solvent extraction method may have residual organic solvents, and requires multiple multi-stage extractions; The efficiency of the method is low, the energy consumption is large, and the components of the extract are not balanced
Due to supercritical CO 2 Extraction is mainly suitable for the extraction of non-polar and weakly polar substances, and there are diketone groups and phenolic hydroxyl groups in the chemical structure of curcumin, which make it have a certain polarity, so what is obtained by this method is mainly turmeric mesopolar The less polar turmeric oil components, while most of the more polar curcuminoids still remain in the raw materials, resulting in incomplete extraction and unbalanced extract components

Method used

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Examples

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Effect test

Embodiment 1

[0029] A microwave-assisted supercritical extraction process for effective components of turmeric uses microwave technology combined with supercritical technology to extract effective components of turmeric under the synergy of the two, including the following specific steps and process conditions:

[0030] Step 1: Microwave pretreatment

[0031] (1) First crush 250g of dried turmeric, pass it through a 20-mesh sieve, then add auxiliary agent water according to the solid-liquid weight ratio (w / w) of 1:0.1, and use microwave heating for 30 seconds each time, at intervals 10 seconds, 4-5 times of microwave action continuously, until the extract solution is heated to 45°C, stop the microwave action;

[0032] Step 2: Extract Turmeric Oil

[0033] (1) Place the turmeric after microwave action in CO 2 in the supercritical extraction kettle, and then turn on the CO 2 The high-pressure pump injects high-pressure CO into the extraction kettle at a flow rate of 3L / h 2 gas;

[0034]...

Embodiment 2

[0041] This method adopts the combination of microwave technology and supercritical technology, and extracts the active ingredients of turmeric under the synergy of the two, including the following specific steps and process conditions:

[0042] Step 1: Microwave pretreatment

[0043] (1) First crush 250g of dried turmeric, pass it through a 30-mesh sieve, then add auxiliary agent water according to the solid-liquid weight ratio (w / w) of 1:0.3, and use microwave heating for 30 seconds each time, at intervals 10 seconds, 5-8 times of microwave action continuously, until the extraction solution is heated to 50°C, stop the microwave action;

[0044] Step 2: Extract Turmeric Oil

[0045] (1) Place the turmeric after microwave action in CO 2 in the supercritical extraction kettle, and then turn on the CO 2 The high-pressure pump injects high-pressure CO into the extraction kettle at a flow rate of 4L / h 2 gas;

[0046](2) The pressure in the extraction kettle is raised to 23MPa...

Embodiment 3

[0053] This method adopts the combination of microwave technology and supercritical technology, and extracts the active ingredients of turmeric under the synergy of the two, including the following specific steps and process conditions:

[0054] Step 1: Microwave pretreatment

[0055] (1) First crush 250g of dried turmeric, pass it through a 40-mesh sieve, then add auxiliary agent water according to the solid-liquid weight ratio (w / w) of 1:0.6, and use microwave heating for 45 seconds each time, with intervals 10 seconds, 4-6 times of microwave action continuously, until the extraction solution is heated to 60°C, stop the microwave action;

[0056] Step 2: Extract Turmeric Oil

[0057] (1) Put the turmeric after microwave action in CO 2 in the supercritical extraction kettle, and then turn on the CO 2 The high-pressure pump injects high-pressure CO into the extraction kettle at a flow rate of 5L / h 2 gas;

[0058] (2) The pressure in the extraction kettle is raised to 23MP...

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Abstract

The invention discloses a process method for microwave assistant supercritical extraction of active ingredients of curcuma. In the method, the active ingredients, namely curcumin and fat soluble curcuma oil, of curcuma are extracted by the synergistic action of the microwave technology and the supercritical technology. The process method mainly comprises the following steps of: performing microwave intermittent sudden heating and then carbon dioxide (CO2) supercritical extraction; separating CO2 and curcuma oil in an analyzing kettle; and adding water or ethanol into curcuma residue in a solid-to-liquid weight ratio of 1:7-14, and performing microwave action, twice soaking, filtration, condensation and spray drying to obtain the curcumin. The process method solves the problem that in the prior art, only single active ingredient can be extracted or the compositions of the extract are not balanced, and realizes the extraction of two main active ingredients, namely curcuma oil and curcumin, of the curcuma at the same time, and the yield is over 8 percent and 13 percent respectively. The process method is the physical method and has the advantages of no product pollution, high purity, low cost, simple process and easy mass production.

Description

technical field [0001] The present invention relates to a CO 2 Supercritical extraction technology and microwave technology specifically refer to a process method for microwave-assisted supercritical extraction of effective components of turmeric. Background technique [0002] Turmeric is a perennial herb belonging to the Zingiberaceae family and has a long history of medicinal use in China and India. Traditional Chinese medicine believes that turmeric rhizome has the effect of breaking Qi, promoting blood circulation, dredging menstruation and relieving pain. Modern medical research shows that the main components of turmeric are curcumin and fat-soluble turmeric oil. Curcumin has anti-oxidation, anti-cancer, anti-human immunodeficiency virus, hypolipidemic and anti-atherosclerosis effects, and turmeric oil has anti-inflammatory effects. Tumor, enhance immunity and so on. [0003] The extraction method of turmeric is generally based on solvent extraction and water vapor e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P3/06A61P9/10A61P31/18A61P35/00A61P37/04A61P39/06
Inventor 张海
Owner GUANGZHOU RZN BIOTECH CO LTD
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