Preparation method and quality detection method of liquorice and gall oral liquid

A technology of Gandan oral liquid and licorice, which is applied in the field of Gandan oral liquid, can solve problems such as not being well adapted to production intensification and scale, rough dosage forms, and inability to fully utilize active ingredients.

Inactive Publication Date: 2010-10-27
BEIJING CENT BIOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional dosage forms of traditional Chinese veterinary medicine are simple in process, rough in dosage form, inconvenient to use, t

Method used

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  • Preparation method and quality detection method of liquorice and gall oral liquid
  • Preparation method and quality detection method of liquorice and gall oral liquid
  • Preparation method and quality detection method of liquorice and gall oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of Gandan oral liquid of the present invention

[0037] Weigh 180g of Radix isatidis, 60g of licorice, and 30g of Xuanming powder, add 2700ml of water to decoct, and collect the decoction; add 2160ml of water to decoct the remaining medicinal residues, and collect the decoction; add 1890ml of water to decoct the remaining medicinal residues, and collect the decoction Combine the three decoctions, filter, concentrate the filtrate to a relative density of 1.18 (50°C), let it cool, add 900ml of ethanol, let it stand, filter, recover the ethanol from the filtrate, add about 240ml of water, and let it stand. Weigh 20g of porcini powder, 20g of artificial bezoar, and 20g of borneol, add 300ml of ethanol to dissolve, add the above extract, add water to 1800ml, shake well, let it stand, and filter to obtain Gandan Oral Liquid 1.

[0038]Weigh 100g of Radix isatidis, 30g of licorice, and 10g of Xuanming powder, add 1400ml of water to decoct, and col...

Embodiment 2

[0043] Embodiment 2: the quality standard research of Gandan oral liquid of the present invention

[0044] The main components of the Gandan oral liquid of the present invention are the tan liquid obtained by water extraction and alcohol precipitation such as licorice, Radix Radix, Calculus Calculus, Borneol, Pig Gall Powder, Xuanming Powder, etc., which are pure Chinese medicine preparations, mainly used for chicken infectious bronchitis, chicken The treatment of infectious laryngotracheitis and mycoplasma gallisepticum has the functions of clearing heat and detoxifying, reducing phlegm and relieving cough. The main bioactive component in licorice is glycyrrhizic acid, and its main pharmacological effect is anti-inflammatory. The anti-inflammatory mechanism is related to the inhibition of mediators such as prostaglandins (PGs). It is generally believed that glycyrrhizic acid can inhibit the synthesis and release of PGs by inhibiting the phospholipase A2 required for the hydro...

Embodiment 3

[0079] Embodiment 3: the stability investigation of Gandan oral liquid of the present invention

[0080] Objective: To investigate the stability of Gandan Oral Liquid of the present invention by taking the properties, identification and content changes of Gandan Oral Liquid as detection indicators, so as to provide scientific basis for clinical application.

[0081] 1 Instruments and Medicines

[0082] 1.1 Instrument

[0083] SHIMADZU LC-10ATVP high performance liquid chromatograph; SPD-10AVP ultraviolet-visible detector; chromatographic column: SHIMADZU ODSC18 column (150×4.6mm, 5μm); Leici PHS-25 digital display pH meter (Shanghai Precision Scientific Instrument Co., Ltd. ).

[0084] 1.2 Reagents

[0085] Glycyrrhizinate monoammonium salt reference substance (National Institute for the Control of Pharmaceutical and Biological Products); Potassium dihydrogen phosphate (analytical pure); Phosphoric acid (analytical pure); Methanol (chromatographically pure); Mobile phase wa...

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Abstract

The invention relates to liquorice and gallbladder oral liquid mainly treating lung heat cough caused by avian infectious bronchitis and mycoplasma gallisepticum infection, oral, injection and spray preparations containing a liquorice and gallbladder composite and a preparation method and a quality detection method thereof. The liquorice and gallbladder oral liquid comprises the components of isatis root, calculus bovis factitius, liquorice, borneol, porcine gall powder, compound of glauber-salt and liquorice and the like. The invention method has simple and convenient production process and advanced detection means; the product has stable quality, high bioavailability, no toxic and side effects, convenient use and obvious curative effect and has the effects of clearing heat and detoxicating, cooling blood and releasing the lung and relieving cough and asthma.

Description

technical field [0001] The invention relates to a Gandan oral liquid for mainly treating chicken infectious bronchitis and lung-heat cough caused by Mycoplasma gallisepticum infection, a preparation method and a quality detection method thereof. Background technique [0002] With the development of my country's poultry industry, especially the rise of intensive and large-scale chicken farms, the large-scale occurrence and prevalence of poultry diseases in various parts of my country in recent years, especially the occurrence of some new poultry diseases, has caused serious damage to the poultry industry. varying degrees of economic loss. Among poultry diseases, respiratory diseases are the most harmful and difficult to control. After investigation, the incidence of poultry infectious respiratory diseases can reach 100%, and the mortality rate varies between 25% and 90% with age. Especially in recent years, the emergence of new mutant strains of some pathogens has led to aty...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K36/704A61K9/00G01N30/90G01N30/02A61P11/00A61P31/00A61P31/04A61K31/045A61K33/04A61K35/413A61K35/56
Inventor 江厚生王秀敏侯晓礁李学良
Owner BEIJING CENT BIOLOGY
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