Application of emodin in preparing medicaments for treating P2X3 mediated neuropathic pains/nerve system diseases

Abstract

The invention relates to novel application of emodin in the field of pharmacy, i.e. the application of emodin in preparing medicaments for treating P2X3 mediated neuropathic pains / nervous system diseases. In experiments, the emodin is observed to have an effect on inhibiting algesia behavioral reaction and is further observed to have an effect on inhibiting the mRNA and protein expression of nerve cell P2X3 receptors of rat dorsal root ganglia in a neuropathic pain model and rat trigeminal ganglion in a trigeminal neuralgia model by applying the technologies of immunohistochemistry, in-situ hybridization, RT-PCR (Reverse Transcription-Polymerase Chain Reaction), protein blotting and the like. The experiments prove that the mechanism of the effect of the emodin on inhibiting chronic pains (neuropathic pains) and pains transmitted by trigeminal ganglion nerve cells is to block algesia information transmission mediated by a primary sensory nerve cell P2X3 receptor. The invention provides a novel method for preventing and treating the pains mediated by the neuropathic pains and / or the trigeminal ganglion nerve cells; meanwhile, the invention shows that the emodin has the effect on influencing the P2X3 receptor, which is beneficial to medicinal application on preventing and treating nerve system diseases related to the P2X3 receptor.

Description

Technical field [0001] The present invention relates to the field of invention of the use of analgesic drugs, in particular to emodin (single use) that can be used to prevent and treat pain in the preparation of P2X 3 Guide the application of neuropathic pain / nervous system disease drugs. Background technique [0002] Pain consists of two parts: pain perception and pain response. It is one of the most common symptoms common to most diseases in clinical practice. It is mainly manifested by the body's damage to tissues or potential damage. An unpleasant subjective reaction. Because pain causes great suffering to people, according to the second issue of the International Pain Association Newsletter in 2001, the United States Congress passed a resolution 106 times, declaring the ten years from January 1, 2001 to be "pain control and Decade of Pain Control and Research" (Decade of Pain Control and Research). This shows that countries attach importance to pain research. According to...

AI Technical Summary

Problems solved by technology

Trigeminal neuralgia is a chronic pain syndrome, and drug therapy is the first choice. Although there are many drugs for treatment, there are few effective drugs with less side effects, and some drugs may be effective at the beginning, but drug resistance will soon develop

Literature reports [Ding Yan, Huang Zhihua. Research progress on pharmacological effects of emodin. Pharmacology and Clinic of Traditional Chinese Medicine, 2007; 23(5): 236-238.] Emodin has anti-inflammatory effect, but there is no direct anti-inflammatory effect of emodin alone. There are no reports on the pain effect of emodin in clinical practice through the mechanism of analgesic effect on pain treatment.

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