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Sugar-lowering drug composition and application

A composition and a technology for hypoglycemic drugs, applied in the field of hypoglycemic drug compositions, can solve problems such as inability to effectively control type 2 diabetes, and achieve the effects of protecting endothelial cell function, reducing diabetic complications, and preventing diabetic complications

Inactive Publication Date: 2010-12-01
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a hypoglycemic pharmaceutical composition and its application, which can effectively solve the defect that type 2 diabetes cannot be effectively controlled by taking commonly used hypoglycemic drugs or vildagliptin alone in the prior art, and at the same time have the functions of effectively controlling blood sugar and synergistic protection. Endothelial cell function, reduction of diabetic complications, etc.

Method used

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  • Sugar-lowering drug composition and application
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  • Sugar-lowering drug composition and application

Examples

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Effect test

no. 1 example

[0021] The hypoglycemic pharmaceutical composition includes 25mg of vildagliptin and 2000mg of metformin.

[0022] Compound metformin and vildagliptin tablet (1000 pieces) preparation method:

[0023] Formula: Metformin 400g

[0024] Vildagliptin 5g

[0025] Starch 100g

[0026] Microcrystalline Cellulose 100g

[0027] Sodium carboxymethyl starch 75g

[0028] Low-substituted hydroxypropyl cellulose 75g

[0029] Proper amount of povidone ethanol solution

[0030] Magnesium Stearate 0.5%

[0031] Preparation method: crush the auxiliary materials in the above formula through a 80-mesh sieve, and dry for later use. Take 400g of metformin and 5g of vildagliptin and mix evenly according to the method of equal increase, add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose respectively according to the formula amount, and mix evenly according to the method of equal increase , use 5% povidone K29...

no. 2 example

[0035] The hypoglycemic pharmaceutical composition includes 50mg of vildagliptin and 1000mg of metformin.

[0036] The preparation method of compound metformin and vildagliptin tablets (1000 tablets) in this embodiment is the same as the preparation of compound metformin and vildagliptin tablets (1000 tablets) in the first embodiment of a kind of hypoglycemic pharmaceutical composition of the present invention The method is the same, the carrier or excipient can be selected or the dose of the carrier or excipient can be adjusted according to the usual technical means in the art to realize the preparation of the pharmaceutical composition.

[0037] In this embodiment, metformin can also be any one of metformin hydrochloride, phenformin or buformin or any combination of the four.

no. 3 example

[0039] The hypoglycemic pharmaceutical composition includes 100mg of vildagliptin and 500mg of metformin.

[0040]The preparation method of compound metformin and vildagliptin tablets (1000 tablets) in this embodiment is the same as the preparation of compound metformin and vildagliptin tablets (1000 tablets) in the first embodiment of a kind of hypoglycemic pharmaceutical composition of the present invention The method is the same, the carrier or excipient can be selected or the dose of the carrier or excipient can be adjusted according to the common technical means in the art to realize the preparation of the pharmaceutical composition.

[0041] In this embodiment, metformin can also be any one of metformin hydrochloride, phenformin or buformin or any combination of the four.

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Abstract

The invention relates to a sugar-lowering drug composition and application thereof. The composition comprises 1) medicinal dosage of vildagliptin and 2) medicinal dosage of any one or combination of thiazolidinedione sugar-lowering drugs or medicinal salt thereof, sulfonylurea sugar-lowering drugs or medicinal salt thereof and biguanide sugar-lowering drugs or medicinal salt thereof. The invention relates to application of the sugar-lowering drug composition to preparing the drugs for treating and / or preventing diabetes or diabetic complications. The composition can effectively overcome the defect that type 2 diabetes can not be controlled by singly taking the commonly used sugar-lowering drugs or vildagliptin in the prior art and can reduce the diabetic complications.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a hypoglycemic pharmaceutical composition with vildagliptin and other hypoglycemic drugs as main active ingredients and its use. Background technique [0002] Diabetes mellitus (Diabetes Inellitus) is a metabolic disease of multiple etiologies, characterized by chronic hyperglycemia, accompanied by disorders of sugar, fat and protein metabolism caused by defects in insulin secretion and / or action. Diabetes can occur at any age. As the course of the disease prolongs, it is easy to cause histopathological damage such as systemic nerve, microvascular and macrovascular lesions, and can lead to chronic and progressive lesions of the heart, brain, kidney, nerves and eyes and other tissues and organs, resulting in Blindness, lower extremity gangrene, uremia, stroke or myocardial infarction will eventually occur, and even life-threatening. With the improvement of living standards, diabete...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K31/155A61K45/00A61K31/4439A61K31/64A61P3/10A61P9/00A61P13/12A61P25/00A61P27/02A61P17/00
Inventor 靳晴于多陈光亮徐希平
Owner 北京奥萨医药研究中心有限公司
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