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Rhizoma corydalis pain-relieving dripping pill preparation and preparation process thereof

A Yuanhu Zhitong Dropping Pill and the technology of the preparation process, which can be applied in the directions of non-central analgesics, pill delivery, anti-inflammatory agents, etc., can solve problems such as slow drug effect, and achieve the effects of convenient operation, short production cycle and few auxiliary materials.

Active Publication Date: 2011-09-21
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the tablets generally need to be disintegrated and dissolved before being absorbed after oral administration, the determination of several batches of samples shows that Yuanhu Zhitong Tablets do not completely disintegrate within 1 hour, and can be disintegrated and dissolved within 1 hour after adding a baffle , therefore, the slow

Method used

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  • Rhizoma corydalis pain-relieving dripping pill preparation and preparation process thereof
  • Rhizoma corydalis pain-relieving dripping pill preparation and preparation process thereof
  • Rhizoma corydalis pain-relieving dripping pill preparation and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 A Yuanhu Zhitong dripping pill preparation is made from the following raw materials: vinegar-made Yuanhu, Angelica dahurica, clove oil, and angelica oil in a weight ratio of 1:1:0.01:0.002.

[0046] Its preparation process comprises the following steps:

[0047] (1) Measure each component according to the formula.

[0048] (2) Pulverize the vinegar-made medicinal materials Yuanhu and Angelica dahurica respectively to a particle diameter of 1-8 mm to obtain Yuanhu powder and Baizhi powder.

[0049] (3) After mixing Yuanhu powder and Angelica dahurica powder evenly, a mixed material is obtained; the mixed material is soaked in ethanol with 1.5 times its weight and a mass concentration of 60% for 18 hours, heated to reflux for 1.5 hours at a temperature of 70° C., and Extraction A and residue were obtained by filtration.

[0050](4) After adding 1.5 times the weight of ethanol with a mass concentration of 60% to the residue, heat and reflux at 70° C. for 1 hour...

Embodiment 2

[0053] Example 2 A Yuanhu Zhitong dripping pill preparation is made from the following raw materials: vinegar-made Yuanhu, Angelica dahurica, clove oil, and angelica oil in a weight ratio of 2:1:0.025:0.006.

[0054] Its preparation process comprises the following steps:

[0055] (1) measure each component by formula;

[0056] (2) Pulverize the vinegar-made medicinal materials Yuanhu and Angelica dahurica respectively until the particle diameter is 1-8 mm to obtain Yuanhu powder and Angelica dahurica powder;

[0057] (3) After mixing Yuanhu powder and Angelica dahurica powder evenly, a mixed material is obtained; the mixed material is soaked in ethanol with 3 times its weight and a mass concentration of 60% for 24h, heated and refluxed at 80°C for 3h, and filtered Obtain extract A and residue;

[0058] (4) After adding ethanol which is 3 times its weight and having a mass concentration of 60% to the residue, heat and reflux at 80° C. for 2 hours, and obtain extract B by filt...

Embodiment 3

[0061] Example 3 A Yuanhu Zhitong dripping pill preparation is made from the following raw materials: vinegar-made Yuanhu, Angelica dahurica, clove oil, and angelica oil in a weight ratio of 3:1:0.05:0.01.

[0062] Its preparation process comprises the following steps:

[0063] (1) measure each component by formula;

[0064] (2) Pulverize the vinegar-made medicinal materials Yuanhu and Angelica dahurica respectively until the particle diameter is 1-8 mm to obtain Yuanhu powder and Angelica dahurica powder;

[0065] (3) After mixing Yuanhu powder and Angelica dahurica powder evenly, a mixed material is obtained; the mixed material is soaked in ethanol with 4.5 times its weight and a mass concentration of 60% for 30 hours, heated and refluxed at 90° C. for 4.5 hours, and Filter to obtain extract A and residue;

[0066] (4) After adding ethanol 4.5 times its weight and having a mass concentration of 60% to the residue, heat and reflux at 90° C. for 3 hours, and obtain extract B...

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Abstract

The invention relates to a rhizoma corydalis pain-relieving dripping pill preparation which comprises the raw materials of vinegar rhizoma corydalis, radix angelicae, caryophyllus oil and angelica oil in the weight ratio of 1:1:0.01:0.002-3:1:0.05:0.01. The invention also discloses a preparation process of the preparation. The preparation has rapid dissolving, quick absorption, quick acting and stable and durable pain-relieving action for various pains, has the functions of regulating vital energy, invigorating blood circulation and relieving pain, and can be used for treating diseases such as stomachache with qi depression to blood stasis, hypochondriac pain, headache, menstrual pain and the like.

Description

technical field [0001] The invention relates to a preparation process of a drop pill preparation, in particular to a Yuanhu Zhitong drop pill preparation and a preparation process thereof. Background technique [0002] Pain is a common symptom. Many diseases can cause pain in the whole body or in a certain part of the body, such as cancer, rheumatoid arthritis, and acute gastroenteritis. Painkillers mainly relieve the uncomfortable symptoms of pain, and some can also treat certain diseases. Among the analgesic drugs currently used clinically in my country, Western medicines account for a large proportion, mainly including central anesthetics such as morphine hydrochloride and pethidine, which have definite effects, but are dependent, cannot be taken for a long time, and must be managed as narcotics. The types of Chinese patent medicines clinically used for pain relief include Yuanhu Zhitong Tablets, Jiuqi Niantong Pills, Zhitong Zijin Pills, Kaixiong Shunqi Pills, Tongjing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P29/02A61P25/04A61K9/20
Inventor 张喜民张建利康永红越庆鑫张东钱双喜邓月婷
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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