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Biosensor system for external actuation of magnetic particles in biosensor cartridge

A biosensor and sensor technology, applied in the measurement of magnetic bead-labeled molecules, magnetic performance measurement, instruments, etc., can solve problems such as unreliable test results

Inactive Publication Date: 2010-12-22
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This can lead to unreliable test results

Method used

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  • Biosensor system for external actuation of magnetic particles in biosensor cartridge
  • Biosensor system for external actuation of magnetic particles in biosensor cartridge
  • Biosensor system for external actuation of magnetic particles in biosensor cartridge

Examples

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Embodiment Construction

[0030] figure 1 An embodiment of a biosensor system 1 comprising a biosensor magnet assembly 10 having for example three electromagnetic subunits 20 a , 20 b and 20 c which may be arranged on a base structure 24 is shown. In a preferred embodiment, each subunit comprises a coil 20a2, 20b2, 20c2 and a core 20a1, 20b1, 20c1 inside the coil. By varying the current flowing through the coils, the magnetic field strength of each subunit can be electrically controlled. In a particular embodiment, the subunits are spaced apart from each other by gaps 22 . Typically, the three subunits 20a to 20c are arranged on the side of the box 30 facing the three subunits. Where the base structure 24 is used, a detachable cartridge 30 is positioned adjacent each subunit such that the biosensor magnet assembly 10 is located between the base structure 24 and the cartridge 30 . The gap 22 may be filled with a dielectric material, such as a plastic material. Furthermore, the cartridge 30 is arran...

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Abstract

The invention provides for a biosensor system (1), wherein the system comprises a biosensor magnet assembly (10) with at least three electromagnetic subunits (20a, 20b, 20c). The magnetic field strength of each electromagnetic subunit is separately changeable by electrical control. Further, the system comprises a detachable biosensor cartridge (30) having a sensor surface and adapted to be arranged with the sensor surface adjacent to the biosensor magnet assembly (10). The invention further provides a method for steering the movement of magnetic particles in a biosensor cartridge (30). The method comprises the steps (a) and (b): in step (a), a sensor surface of a detachable biosensor cartridge (30) is arranged adjacent to a biosensor magnet assembly (10). The biosensor magnet assembly comprises three electromagnetic subunits (20a, 20b, 20c), wherein the magnetic field strength of each subunit is separately changeable by electrical control. In step (b), the magnetic field strength of each subunit is separately changed by electrical control to obtain a magnetic field gradient in the biosensor cartridge (30).

Description

technical field [0001] The present invention relates to a biosensor system comprising a biosensor cartridge and a biosensor magnet assembly having at least three electromagnetic subunits used on one side of the biosensor cartridge, and relates to a The method of magnetic particle motion. Background technique [0002] Various analytical procedures are known for detecting analytes in test samples. For example, immunoassays use mechanisms of the immune system in which antibodies and respective antigens are able to bind to each other. This specific reaction mechanism is used to determine the presence or concentration of antigen in the test sample. [0003] Specifically, either the antibody or the antigen (analyte of interest) is labeled to quantify the interaction between the antibody and antigen. Common labels are, for example, fluorescent and chemiluminescent molecules, colored particles (beads) or radioactive isotopes. [0004] More recently, magnetic labels have been use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N35/00G01R33/12
CPCG01N33/54373G01R33/1269G01N27/745
Inventor M·奥夫扬科P·J·W·范兰卡威尔特
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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