Detection of curative effects of tamoxifen in auxiliary treatment of breast cancer

A tamoxifen and adjuvant therapy technology, applied in the fields of molecular biology and medicine, can solve problems such as loss of large fragments of genes, shifting of reading frames, etc.
CN101928752AInactive Publication Date: 2010-12-29HAINAN ZHUJIAN CELL MOLECULE GENETICS INSPECTION CENT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HAINAN ZHUJIAN CELL MOLECULE GENETICS INSPECTION CENT
Publication Date
2010-12-29
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention discloses a kit for detecting curative effects of individual tamoxifen in auxiliary treatment of breast cancer. The kit comprises a specific primer pair and a specific fluorescent probe pair for detecting the polymorphic site of a target site CYP2D6 gene of tamoxifen administration, a quantitative polymerase chain reaction (PCR) conventional component and the like. The kit of the invention evaluates the curative effects of the individual tamoxifen in the auxiliary treatment of breast cancer by detecting the polymorphic site of the target site CYP2D6 gene of tamoxifen administration.
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Description

technical field

[0001] The present invention relates to the fields of molecular biology and medicine. More specifically, the present invention relates to a kit for detecting the curative effect of individual tamoxifen adjuvant treatment of breast cancer, by detecting the polymorphism of the CYP2D6 gene at the site targeted by tamoxifen sites to assess the efficacy of individual adjuvant tamoxifen therapy in breast cancer. Background technique

[0002] Breast cancer is a disease in which ductal epithelial cells of the mammary gland lose their normal characteristics and proliferate abnormally under the action of various internal and external carcinogenic factors, so that they exceed the limit of self-repair and become cancerous. The main clinical manifestation is breast lumps. Breast cancer is one of the most common malignant tumors in women. It has the characteristics of high incidence, aggressiveness, slow progression and long natural survival period.

[0003] Breast cancer...

Claims

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