Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel process for the preparation of vorinostat

A vorinostat, stand-alone technology for the preparation of active pharmaceutical ingredients vorinostat that addresses issues that limit the feasibility of commercial production scale, reduce overall yield, etc.

Inactive Publication Date: 2011-01-05
GENERICS UK LTD
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This reduces the overall yield and severely limits the viability of the method for commercial production scale

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel process for the preparation of vorinostat
  • Novel process for the preparation of vorinostat
  • Novel process for the preparation of vorinostat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0079] Vorinostat

[0080]Suberic acid (1.0 eq) was dissolved in tetrahydrofuran (15 vol), and the clear solution was cooled to 0-5°C. Methyl chloroformate (1.1 eq) and triethylamine (1.1 eq) were added to the solution at the same temperature and the mixture was stirred for 15 minutes. The formed triethylamine hydrochloride was filtered off, then aniline (1 eq) was added to the reaction mixture at 0-5°C and stirring was continued for 15 minutes. Methyl chloroformate (1.1 eq) and triethylamine (1.1 eq) were added to the clear solution and stirring was continued for a further 15 minutes at 0-5°C. The cooled reaction mixture was added to fresh methanolic solution of hydroxylamine (*see below) cooled to 0-5°C and stirred at 0-5°C for 15 minutes. The solvent was removed under vacuum at 40°C, the obtained residue was taken up in dichloromethane and the organic solution was washed with water and dried over anhydrous sodium sulfate. The dichloromethane was removed under vacuum at 4...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient, vorinostat. In particular it relates to an efficient process for the preparation of vorinostat of high purity without the requirement to isolate any synthetic intermediate compounds.

Description

technical field [0001] The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to an efficient process for the preparation of high-purity vorinostat without isolating any synthetic intermediate compounds. Background technique [0002] Vorinostat, also known as suberoylanilide hydroxamic acid (SAHA) or N-hydroxy-N'-phenylsuberamide, is represented by structural formula (I). [0003] [0004] Vorinostat is a histone deacetylase (HDAC) inhibitor currently marketed for the treatment of cutaneous T-cell lymphoma (CTCL), a type of skin cancer. Since vorinostat is considered to be able to selectively induce late differentiation of tumor cells and thereby inhibit the proliferation of such cells under suitable conditions, vorinostat is used for the treatment of patients with tumors characterized by continuous proliferation of tumor cells. tumor patients. [0005] Processes for the prep...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C259/06A61K31/167
CPCC07C259/06A61P35/00
Inventor 阿沛·盖顿德巴拉蒂·乔杜里
Owner GENERICS UK LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com