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Graft materials and methods for staged delivery of bioactive components

A technology of biologically active components and material layers, which can be used in drug combinations, non-central analgesics, medical science, etc., and can solve the problems of inability to complete the wound healing process and lack of resistance.

Active Publication Date: 2011-02-09
COOK BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With chronic wounds, the body cannot complete the wound healing process due to a lack of resistant blood vessels and / or immune system

Method used

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  • Graft materials and methods for staged delivery of bioactive components
  • Graft materials and methods for staged delivery of bioactive components
  • Graft materials and methods for staged delivery of bioactive components

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Embodiment Construction

[0017] While the invention may be embodied in many different forms, for purposes of facilitating an understanding of the principles of the invention, reference will now be made to specific embodiments illustrated in the drawings and specific language will be used to describe the same. It should however be understood that this is not intended to limit the scope of the invention. Any alterations and further modifications in the specific embodiments described, and any further applications of the principles of the invention described herein, will normally occur to those skilled in the art to which the invention relates.

[0018] As noted above, in certain aspects, the present invention provides unique multilayer medical graft products comprising first and second bonded layers of material relating to one or more The incorporation or degree of incorporation of the two biologically active components differs from one another. For example, a preferred multilayer medical graft product ...

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Abstract

Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of the invention comprises a first layer of remodelable extracellular matrix (ECM) material bonded to a second layer of remodelable ECM material, wherein the first material layer is enriched with a growth factor relative to the second material layer. Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).

Description

[0001] References to related applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 61 / 036,613, entitled GRAFT MATERIALS AND METHODS FOR STAGED DELIVERY OF BIOACTIVE COMPONENTS, filed March 14, 2008, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates generally to medical devices and, in a particular aspect, to tissue transplantation devices comprised of layers of extracellular matrix material having mutually different properties. Background technique [0004] As further background, when tissue is damaged or destroyed by disease, trauma, including surgery or any other means, a series of interdependent physiological phenomena occur leading to tissue repair. These phenomena occur within (or in relation to) what is generally considered to be the four major healing phases: inflammation, cellular proliferation, matrix deposition and remodeling. Tissue wound healing is a dy...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/36A61L27/54
CPCA61L2300/414A61L27/3633A61L15/44A61L2300/608A61L27/54A61L15/40A61P17/02A61P29/00A61P31/04A61P43/00
Inventor A·D·贾尼斯
Owner COOK BIOTECH
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