3,4-dichlorophenyl-propenoyl-sec-butylamine composition

A technology of chloramidine and its composition, which is applied in the field of pharmaceutical compositions for treating epilepsy, can solve the problem of chloramidine being insoluble in water, etc., and achieve the effect of improving the dissolution rate

A technology of chloramidine and its composition, which is applied in the field of pharmaceutical compositions for treating epilepsy, can solve the problem of chloramidine being insoluble in water, etc., and achieve the effect of improving the dissolution rate

CN101991561AInactive Publication Date: 2011-03-30DISHA PHARMA GRP
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  • 3,4-dichlorophenyl-propenoyl-sec-butylamine composition

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Effect test

Embodiment 1

[0025] Prescription: chloramidine 100g, lactose 5g, sodium starch glycolate 45g, povidone (K30) 4.5g, magnesium stearate 1.6g, micropowder silica gel 1.6g, make 1000 tablets or 1000 capsules according to the above preparation method .

Embodiment 2

[0027] Prescription: chloramidine 100g, lactose 20g, sodium starch glycolate 30g, povidone (K30) 4.5g, magnesium stearate 1.6g, micropowder silica gel 1.6g, make 1000 tablets or 1000 capsules according to the above preparation method .

Embodiment 3

[0029] Prescription: 100g of chloramidine, 20g of lactose, 7.9g of sodium starch glycolate, 22g of microcrystalline cellulose, 4.5g of povidone (K30), 1.6g of magnesium stearate, 1.6g of micropowder silica gel, prepared according to the above-mentioned preparation method Comes in 1000 tablets or 1000 capsules.

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Abstract

The invention relates to a 3,4-dichlorophenyl-propenoyl-sec-butylamine composition for treating epilepsy. The 3,4-dichlorophenyl-propenoyl-sec-butylamine composition is characterized by containing 3,4-dichlorophenyl-propenoyl-sec-butylamine and sodium carboxymethyl starch. The 3,4-dichlorophenyl-propenoyl-sec-butylamine and the sodium carboxymethyl starch are reasonably compounded, thereby increasing the dissolution rate of the pharmaceutical composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating epilepsy. Background technique [0002] The prevalence of epilepsy in my country is 7‰, which is close to the incidence rate of 7.2‰ in developing countries reported by WHO. At present, the number of epilepsy patients in my country has exceeded 10 million, and there are nearly 400,000 new cases every year. Among these patients with epilepsy, children and adolescents still have a high incidence of epilepsy. Patients aged 0-9 accounted for 38.5%, and patients aged 10-29 accounted for nearly 40%. Among them, more than 40% of patients had never received treatment, and 35% of patients received informal treatment. [0003] Chlorocinamide is an aromatic acrylamide derivative, which is the abbreviation of 3,4-dichlorocinnamic acid butylamine, and its chemical name is: (1S,1R)-(E)-3-(3,4 -dichlorophenyl)-N-(1-methylpropyl)-2-acrylamide. The compound belongs to a cinnamon amide derivative, an...

Claims

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Application Information

Patent Timeline
30 Mar 2011
Publication
CN101991561A
IPC
A61K31/165; A61K47/36; A61P25/08
Inventors
龙连清; 李宗文