Application of Incarvillea delavay alkali in preparing drug for resisting autoimmune diseases and graft rejection diseases

An autoimmune disease, pineapple alkaloid technology, applied in metabolic diseases, skin diseases, bone diseases and other directions, can solve the problems of cell non-specificity, increase the economic burden of patients, and high prices, achieve inhibition of occurrence and development, save treatment costs, Source-rich effects
CN102008468BInactive Publication Date: 2012-11-21SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2012-11-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an application of Incarvillea delavay alkali in preparing a drug for resisting autoimmune diseases and graft rejection diseases. Experiments show that the Incarvillea delavay alkali can inhibit human dendritic cell proliferation in vitro, prevent the human dendritic cells from accelerating the proliferation reaction of allogeneic T cells, and strengthen the capability of the human dendritic cell on secreting interleukin. Meanwhile, in the model of the experimental autoimmune disease cerebrospinal meningitis, the Incarvillea delavay alkali is applied in vivo so as to lower average clinical scores of mice and inhibit the spinal cord infiltration degree of mononuclear cells. In a heart transplantation experiment, the Incarvillea delavay alkali is applied in vivo to prolong the survival time of a transplanted heart. In a delayed hypersensitivity reaction model, the Incarvillea delavay alkali is applied in vivo to lower the auricle swelling degree of the mice. In-vivo and in-vitro results show that the Incarvillea delavay alkali has certain action on resisting autoimmune diseases and graft rejection diseases. The drug provided by the invention is a preparation composed of the Incarvillea delavay alkali which serves as an active ingredient, and a medicinal carrier. The drug can be in an oral agent form, an injection form, a suppository form or an external dosage form and the like.
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Description

technical field

[0001] The present invention relates to medicines. It specifically relates to the preparation of medicines with new indications, especially the application of bromelain in the preparation of medicines against autoimmune diseases and transplantation rejection diseases. Background technique

[0002] Existing immunosuppressants mainly contain cyclosporine A (CsA), corticosteroids, rapamycin, etc. Most of them have obvious adverse reactions, such as nephrotoxicity and non-specificity to cells, etc., and the price is high, increasing patient financial burden. How to use traditional Chinese medicine and its active ingredients to prevent and treat autoimmune diseases and transplant rejection is one of the important directions of modernization research of traditional Chinese medicine.

[0003] Bromelain is an alkaloid derived from red pineapple flowers.

[0004] At present, it has been found that red pineapple flower can treat postpartum hypogalactia, physical wea...

Claims

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