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Application of galangal extract in preparation of medicine for inhibiting calcium channel

A technology of calcium ion channels and calcium ions, which is applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems that no research has shown the inhibitory effect of galangal, and achieve good application prospects

Inactive Publication Date: 2012-05-30
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, no studies have yet shown the inhibitory effect of galangal on TRPC channels, and the use of galangin in the prevention and treatment of cardiovascular and cerebrovascular diseases

Method used

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  • Application of galangal extract in preparation of medicine for inhibiting calcium channel
  • Application of galangal extract in preparation of medicine for inhibiting calcium channel
  • Application of galangal extract in preparation of medicine for inhibiting calcium channel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 galanga total flavonoids 1

[0025] 10 kg of galangal, 10 times 95% ethanol reflux extraction for 2 hours, 8 times 95% ethanol reflux extraction for 1 hour, combined extracts, recovered under reduced pressure until no alcohol smell.

[0026] Equal volumes of ethyl acetate were extracted for 3-4 times (indicated by the color reaction of galangin or flavonoids), and the ethyl acetate extracts were combined. Recover ethyl acetate, disperse the recovered product with 20% ethanol, apply macroporous resin, elute with 30% ethanol for 2 column volumes, and then use 70% ethanol for 5 column volumes to obtain total flavonoids of galanga. See attached picture 2 for the extraction route

Embodiment 2

[0027] The preparation of embodiment 2 galangal total flavonoids 2

[0028] 10 kg of galangal, 10 times 95% ethanol reflux extraction for 2 hours, 8 times 95% ethanol reflux extraction for 1 hour, combined extracts, recovered under reduced pressure until no alcohol smell.

[0029] On the macroporous resin, first eluted with water for 5 column volumes, and then 30% ethanol for elution, taking the color reaction of flavonoids as an indicator, eluted for 5 column volumes; Total flavonoids of ginger. See attached for extraction route image 3

Embodiment 3

[0030] The preparation of embodiment 3 galanga total flavonoids tablet

[0031] The total flavonoids extract of galanga was prepared according to the method described in Example 1, and the extract was dried below 80°C and passed through a 60-80 mesh sieve, and 200 grams of effective parts of total flavonoids of galanga were taken, and an appropriate amount of microcrystalline cellulose and stearin were added Magnesium acid, mixed, dry pressed into 1000 tablets.

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Abstract

The invention aims to extend application of a galangal extract which contains galangin and is used to inhibit the calcium channel, in particular TRP (Transient ReceptorPotential) channel, so as to prevent and treat heart cerebrovascular diseases such as atherosclerosis and the like. The TRP channel is a non-selective cation channel and has a close relation with heart cerebrovascular diseases suchas atherosclerosis and the like. By inhibiting the activity of TRPC channel of vascular endothelial cells, the vascular function can be improved obviously and the vascular pathological changes of atherosclerosis can be improved obviously too. Chemical protection, antioxidation, antiviral and antibacterial action, anti-cancer effect of galangin are further explored previously and the invention extends the use of the galangal extract to prepare medicine for preventing and treating heart cerebrovascular diseases.

Description

technical field [0001] The present invention relates to the application of a galangin extract containing galangin in the preparation of drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases such as hypertension and atherosclerosis, in particular to the application of galangin in the preparation of galangin by inhibiting the transient receptor cation channel (transient receptor potential, TRP), and then inhibit the application of calcium ion influx. Background technique [0002] Transient receptor cation channels (TRP channels) are transmembrane proteins that, when activated, allow the transmembrane transport of cations, including calcium ions. Unlike other calcium channels such as voltage-gated channels and ligand-gated channels that participate in relatively specialized cellular functions, the TRP family is fascinating because of its universality and diversity of potential cellular functions. TRP genes are quite conserved in phylogenetic tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P9/00A61P9/10A61K125/00
Inventor 杨洪军游云黄璐琦吴宏伟陈畅
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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