NIR online detection method for paeoniflorin content of white paeony root extract

A detection method and a technology of extracting liquid, which are applied in the field of traditional Chinese medicine research to achieve the effects of simple operation, no pollution and accurate results

Active Publication Date: 2011-05-18
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Abstract
  • Description
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Problems solved by technology

Research on near-infrared on-line detection technology based on the production-scale alcohol extraction and concentration process of traditional Chinese medicine has not been reported yet

Method used

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  • NIR online detection method for paeoniflorin content of white paeony root extract
  • NIR online detection method for paeoniflorin content of white paeony root extract
  • NIR online detection method for paeoniflorin content of white paeony root extract

Examples

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Embodiment 1

[0028] This example intends to realize the online detection of the paeoniflorin content in the alcohol extraction process of white peony by the method of the present invention, so as to realize effective online quality control.

[0029] The near-infrared spectrum acquisition instrument involved in this embodiment is an ANTARIS Fourier near-infrared analyzer (Thermo Company, USA), equipped with optical fiber accessories and TQ Analyst analysis software. The HPLC instrument involved in this embodiment is an Agilent 1100 high performance liquid chromatograph (HP Company, USA). This embodiment also relates to a 500L multifunctional extraction device (Tasly Modern Chinese Medicine Resources Co., Ltd.).

[0030] The Radix Paeoniae Alba (origin in Anhui) used in this example was identified as Radix Paeoniae Alba (RADIX PAEONIAE ALBA) by the Quality Inspection Department of Tasly Modern Chinese Medicine Resources Co., Ltd. The paeoniflorin reference substance used in HPLC analysis wa...

Embodiment 2

[0058] This example intends to use the method of the present invention to realize online detection of the content of paeoniflorin in the process of concentrating the alcohol extract of white peony on an industrial scale, so as to realize effective online quality control.

[0059] In this example, on the basis of Example 1, a concentrator of the alcoholic extract of Paeoniae Alba is also used—a 300L plate-type concentrator (Tasly Modern Chinese Medicine Resources Co., Ltd.).

[0060] The integrated process of alcohol extraction and concentration in this embodiment includes, for each batch of Radix Paeoniae Alba, also weighing 50 kg of medicinal materials, placing them in a 500L extraction tank, adding 5 times the amount of 60% ethanol to decoct and extract twice, each time 1 hour. The alcohol extract was concentrated with a plate concentrator to a relative density of 1.08-1.10 (60°C). During the concentration process, online spectra were collected once every 2-5 minutes, and 2...

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Abstract

The invention discloses a near infrared (NIR) online detection method for paeoniflorin content of white paeony root extract, and belongs to the technical field of Chinese medicament research. The method comprises the following steps of: a) acquiring near infrared spectrum and paeoniflorin content of white paeony root extract samples of set number; b) establishing a detection model by a partial least squares method according to the near infrared spectrum and the paeoniflorin content; and c) acquiring the near infrared spectrum of the white paeony root extract sample to be detected on line, and inputting the near infrared spectrum to the detection model to obtain the paeoniflorin content of the sample to be detected so as to realize online detection of the paeoniflorin content of the white paeony root extract. The method can be used for an alcohol extraction process of white paeony root, and can also be used for a concentration process of the white paeony root alcohol extract. The method can be used for detection and quality monitoring of Chinese medicaments.

Description

technical field [0001] The invention relates to near infrared (Near Infrared, NIR) spectrum technology, in particular to an NIR online detection method for paeoniflorin content in Radix Paeoniae Alba extract. It belongs to the technical field of traditional Chinese medicine research. Background technique [0002] The control mode of the current Chinese medicine production process in my country basically remains on the traditional empirical control method, which rarely considers the composition and content changes in the process, and the control is too simple to achieve on-line detection and quality monitoring of the production process. Realizing the online real-time quality monitoring of the production process is the key to ensure the stable and uniform quality of traditional Chinese medicine, and it is also the technical bottleneck to realize the modernization of traditional Chinese medicine production. [0003] Near-infrared spectroscopy is a rapid analytical technique th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71G01N21/35G01N30/36G01N21/359
Inventor 张金巍张延莹刘岩贾铭赵国磊
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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