Production method of long carbon chain dibasic acid

A long-chain dibasic acid and production method technology, which is applied in the field of bioengineering, can solve the problems of slow development of downstream products of long-chain dibasic acid, backward production technology and equipment, and failure to meet customer needs, etc., and achieve a step-by-step reduction Effects of cultivation process, shortened production cycle, and low production cost

Active Publication Date: 2021-04-02
CATHAY R&D CENT CO LTD +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] 2. The production technology and equipment are backward, and the product grade is low
[0011] 4. The product is single, and the production of long-chain dibasic acid series products has not been formed, which cannot meet the needs of the market
[0012] 5. Insufficient investment in research and development, slow development of downstream products of long-chain dibasic acids
[0013] 6. The detection technology is backward and cannot meet the needs of customers

Method used

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  • Production method of long carbon chain dibasic acid
  • Production method of long carbon chain dibasic acid
  • Production method of long carbon chain dibasic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047]Fermentation control conditions:

[0048]Volume: 8%, can temperature: 25 ° C, ventilation ratio: 1: 0.3VVM, tank pressure: 0.08MPa, pH: 1 post-addition hydrocarbon 4.0, after adding alkanes: 120 hours.

[0049]Replenishment control parameters:

[0050]Alkane: When the growth concentration of the bacteria is greater than (OD6200.8, start supplementing cell regulators and alkanes, adding cellular regulators disposable, and alkane control concentration in fermentation broth is 3%, and the feed is stopped 20 hours before fermentation.

[0051]The extraction process of the fermentation liquid:

[0052]The fermentation broth was heated to a fermentation liquid storage tank by a steam heater to 70 ° C. After the liquid, the alkali is added to the fermentation fluid pH to 8.5 to 8.5 to which the membrane is separated by the membrane filtration. The dibasic acid is added to the active carbon. After 50 ° C for 40min, then filtrate to obtain concentrated sulfuric acid to acidification PH2.5, 80 ° C was...

Embodiment 2

[0056]Fermentation control conditions:

[0057]The amount of inoculation: 10%, tank temperature: 30 ° C, ventilation ratio: 1: 0.5VVM, tank pressure: 0.10 MPa, pH: 5.0 before the sinking hydrocarbon 5.5, 7.5, Culture time: 140 hours.

[0058]Replenishment control parameters:

[0059]Alkane: When the growth concentration of the bacteria is greater than (OD6200.8, starting to supplement cell regulators and alkanes, add cell regulators for one-time addition, and alkane control concentration in fermentation broth is 7%, and the feed is stopped 20 hours before fermentation.

[0060]The extraction process of the fermentation liquid:

[0061]The fermentation broth was heated to a fermentation liquid tank by a steam heater to 70 to 90 ° C. After the liquid, the alkali was added to 9.5, separated by membrane filtration, and a dibasic acid tank was added to 80 min after 65 ° C, and then filtered to obtain a decolorized liquid for concentrated sulfuric acid to pH3. .5, 88 ° C Incubate for 34 hours, acidified...

Embodiment 3

[0065]Fermentation control conditions:

[0066]The amount of inoculation: 20%, can temperature: 35 ° C, ventilation ratio: 1: 0.7VVM, can press: 0.12 MPa, pH: 1.0 before the addition of alkanes, 8.5 after extractance, culture time: 160 hours.

[0067]Replenishment control parameters:

[0068]Alkane: When the growth concentration of the bacteria is greater than (OD6200.8, start supplementing cell regulators and alkanes, adding cellular regulators disposable, and alkane control concentration in fermentation broth is 10%, and the feed is stopped 20 hours before fermentation.

[0069]The extraction process of the fermentation liquid:

[0070]The fermentation broth was heated to a fermentation liquid tank by a steam heater to 70 to 90 ° C. Later, the alkali was added to the fermentation liquid pH to 10.5, separated by membrane filtration, and 1.0% activated carbon was added, and 120 min was decolored by 120 min, and then the decolorized liquid was acidified to pH5. .0, 95 ° C for 4 hours, acidified cry...

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Abstract

The invention relates to a preparation method of a long carbon chain dibasic acid. C11 and upper alkane is used as a substrate to produce a corresponding long carbon chain dibasic acid product through the conversion of the substrate into the long carbon chain dibasic acid by using a microbial fermentation method as well as the extraction and the separation of fermentation liquid and the refining processes of a crude product of dibasic acid. Through technological innovation and process innovation, the invention researches a new preparation method of the long carbon chain dibasic acid, greatly decreases the production cost of the long carbon chain dibasic acid, improves the yield and the product quality of the long carbon chain dibasic acid, can produce C11 and upper long carbon chain dibasic acid, finally solve the bottleneck problem restricting the rapid development of the long carbon chain dibasic acid, and form the industrialized scale and the technological predominance. The long carbon chain dibasic acid produced by using the bioanalysis provided by the invention has the advantages of high acid generation level, low production cost, good product quality, complete variety, and the like, the prepared long carbon chain dibasic acid product has high single acid content, good light transmission and high thermal stability, can meet the requirements of different clients, and can be used for producing high-grade spices, high-performance engineering plastics, high-temperature dielectric medium, high-grade hot-melt adhesive, coldness-resistant plasticizer, high-grade lubricating oil, high-grade paint, coating, and the like. The invention greatly widens the development space of the downstream products of the long carbon chain dibasic acid.

Description

Technical field[0001]The invention is a biological engineering field, and a method of producing a long-carbon chain diomerate product using a biological method.Background technique[0002]Long Chain Dicarboxy Acids refers to an aliphatic dicarboxylic acid (DCN) containing more than 10 carbon atoms in the carbon chain, including saturation and unsaturated dicarboxylic acid, is an important and extensive. Industrial use of fine chemical products, are important raw materials such as synthetic advanced spices, high-performance engineering plastics, high temperature dielectrics, high-grade hot melt adhesive, high-temperature plastic agents, high-grade hot melt adhesive, high-temperature plastic agents, high-grade hot melt adhesive, high-temperature plasticizer, high-grade lubricants, advanced paints and coatings.[0003]Production method of long-carbon chain diacholytic acid has chemical synthesis and biological fermentation method, which is mainly produced by chemical synthesis method. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/64C12R1/74
Inventor 雷光刘福来高冰李乃强杨玉峰刘文凤欧阳跃明
Owner CATHAY R&D CENT CO LTD
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