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Ordered mesoporous silica material

A technology of mesoporous silicon oxide and pore size, which is applied in the direction of silicon oxide, silicon dioxide, thin material processing, etc.

Inactive Publication Date: 2011-05-18
FORMAC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention solves the following problems in the related field: in order to prepare a material with a mesopore diameter of 4-30 nanometers, preferably 7-30 nanometers, particularly preferably 11-30 nanometers, more preferably 15-30 nanometers, and not in the preparation process Using or not adding aromatic hydrocarbons such as 1,2,4-trimethylbenzene, it is necessary to adopt harsh acidic conditions (pH9)
[0008] The present invention also solves the problem in the related art of preparing substantially homogeneous materials with mesopore diameters greater than 10 nm without using or having to add aromatic hydrocarbons such as 1,2,4-trimethylbenzene to the reaction mixture. , you must use harsh acidic conditions (pH9) in the reaction mixture

Method used

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  • Ordered mesoporous silica material
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  • Ordered mesoporous silica material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0195] Example 1 Under the condition that the pH of the reaction mixture is equal to 5.8, TPAOH (SiO 2 / TPAOH=25 / 1) to synthesize COK-10

[0196] In a polypropylene (PP) container (500 ml), mix 4.181 g of Pluronic P123 surfactant (BASF) with 107.554 g of water, 12.64 g of HCl solution (2.4M) and 1.8 ml of 1M tetrapropylammonium hydroxide (TPAOH ) solution [purchased from Alpha Corporation (Alpha)] was mixed. The vessel was placed in a 35°C oil bath and stirred (400 rpm) overnight with a magnetic stir bar. In the second PP receiver, 10.411 g of sodium silicate solution [RdH company (Riedel de ), pure, at least 10% by weight NaOH and at least 27% by weight SiO 2 ] mixed with 30.029 grams of water. The mixture was stirred (400 rpm) with a magnetic stir bar for 5 minutes at room temperature. The latter solution was added to the PP container in the oil bath. The resulting solution was stirred (400 rpm) at 35°C for 5 minutes. In this step, the Mettler Toledo An Expert Pro ...

Embodiment 2

[0197] Example 2 Under the condition that the pH of the reaction mixture is equal to 2.4, TPAOH (SiO 2 / TPAOH=25 / 1) to synthesize COK-10

[0198] In a PP container (500 mL), 4.162 g of Pluronic P123 surfactant was mixed with 107.093 g of water, 13.039 g of HCl solution (2.4M) and 1.8 mL of 1M TPAOH solution (purchased from Alpha Corporation). The vessel was placed in a 35°C oil bath and stirred (400 rpm) overnight with a magnetic stir bar. In the second PP receiver, 10.441 grams of sodium silicate solution (RdH company, pure, at least 10% by weight NaOH and at least 27% by weight SiO 2 ) was mixed with 30.027 grams of water. The mixture was stirred (400 rpm) with a magnetic stir bar for 5 minutes at room temperature. The latter solution was added to the PP container in the oil bath. The resulting solution was stirred (400 rpm) at 35°C for 5 minutes. In this step, the Mettler-Toledo An Expert Pro pH electrode measured a pH of 2.4. The resulting reaction mixture was plac...

Embodiment 3

[0201] Example 3 Under the condition that the pH of the reaction mixture is equal to 6.4, no TPAOH is used to synthesize a mesoporous material (comparative example)

[0202] In a PP container (500 mL), 4.212 grams of Pluronic P123 surfactant was mixed with 107.592 grams of water, 12.630 grams of HCl solution (2.4M) and 0.066 grams of NaOH. The vessel was placed in a 35°C oil bath and stirred (400 rpm) overnight with a magnetic stir bar. In the second PP receiver, 10.413 grams of sodium silicate solution (RdH company, pure, at least 10% by weight NaOH and at least 27% by weight SiO 2) mixed with 30.020 g of water. The mixture was stirred (400 rpm) with a magnetic stir bar for 5 minutes at room temperature. The latter solution was added to the PP container in the oil bath. The resulting solution was stirred (400 rpm) at 35°C for 5 minutes. In this step, the Mettler-Toledo An Expert Pro pH electrode measured a pH of 6.4. The resulting reaction mixture was placed in a prehe...

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Abstract

A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.

Description

technical field [0001] The present invention relates to a method for self-assembling ordered mesoporous silica materials and two-dimensional hexagonal ordered mesoporous silica materials in a reaction mixture under weakly acidic or neutral pH conditions. Furthermore, the present invention also relates to ordered mesoporous materials having a narrow (essentially uniform) mesoporous pore size distribution obtained by the method described above. Background technique [0002] In the past, several types of ordered mesoporous silica materials have been synthesized using strongly acidic (pH<2) or strongly basic (pH>9) reaction conditions. The use of surfactants and amphiphilic polymers as structure directing agents for ordered mesoporous silica materials is well known in the art. Kresge et al. (Nature 1992, 359, 710-712) report the synthesis of an MCM-41 material with tubular mesopores arranged hexagonally. The synthesis of MCM-41 is carried out under alkaline conditions us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B37/02A61K9/16
CPCC01B37/02A61K47/02A61K9/143Y10T428/249979
Inventor J·贾玛尔A·阿尔茨G·范登穆特J·马藤松
Owner FORMAC PHARMA