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Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases
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A technology of dimethylchalcone and methoxy, which is applied in application, food preparation, drug combination, etc., to achieve the effect of reducing AST value, alleviating mouse mania, and reducing ALT value
Inactive Publication Date: 2011-05-25
EAST CHINA UNIV OF SCI & TECH
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[0006] There is no 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (2',4'-dihydroxy-6'-methoxy-3',5' -dimethylchalcone, DMC) for the relevant reports on protecting the liver
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Embodiment 1
[0016] Example 1 2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone's protective effect on CCl4-induced acute liver cell injury
[0019] CCl4 (Shanghai Lingfeng Chemical Reagent Co., Ltd., analytically pure), biphenyl diester (BDP) (Jiangsu Pengyao Pharmaceutical Co., Ltd.), DMSO (Shanghai Chemical Reagent Company, analytically pure), dipotassium hydrogen phosphate and dihydrogen phosphatePotassium is analytically pure;
[0020] DMC, 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone, is extracted and isolated from Hydrangea flower in the laboratory, with a purity of >98% (HPLC) .
[0023] Select a newborn mouse of about 10 g, fast for 24 hours, decapitate the blood, separate the liver aseptically, weigh it, place it in PBS solution, wash the liver until gray...
Embodiment 2
[0033] Example 2 2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone's protective effect on CCl4-induced acute liver injury in mice
[0034] Reagents and Drugs:
[0035] ALT (alanine aminotransferase) detection kit and AST (aspartate aminotransferase) detection kit were purchased from Nanjing Jiancheng Biotechnology Co., Ltd.;
[0037] DMC, 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone, is extracted and isolated from Hydrangea flower in the laboratory, with a purity of >98% (HPLC) .
[0038] Kunming mice, weighing (25±2) g, male and female, were purchased from Shanghai Slack Experimental Animal Co., Ltd.
[0039] Experimental method and results:
[0040] 60 Kunming mice were rando...
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Abstract
The invention relates to a use of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of liver-protecting medicaments, foods or health care products. The invention further relates to a use of the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in the preparation of the medicaments, the foods or the health care products for treating or preventing liver diseases and complications thereof. The 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone is found to have an obvious protecting role for in vitro liver cell injuries through the research of the invention, and can be used for preparing the liver-protecting medicaments, the foods or the health care products; and the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone further has an obvious repair role for in vivo liver organ injuries, and can be used for preparing the medicaments, the foods or the health care products for treating or preventing liver diseases and the complications thereof, thereby bringing the gospel to patients with the liver diseases and being applicable to large-scale popularization and application.
Description
technical field [0001] The present invention relates to the technical field of application of compounds, in particular to the technical field of application of chalcones, specifically a 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethyl Application of chalcone in preparation of medicine for treating liver diseases. Background technique [0002] my country is an area with a high incidence of liver disease, and hepatitis patients account for more than 10% of the total population. At present, anti-hepatitis drugs commonly used in clinic can be roughly divided into three categories: antiviral drugs, immunomodulatory drugs and hepatoprotective drugs. At present, there are 12 million people in the country suffering from chronic liver disease, and 300,000 people are killed by liver disease every year. It is noteworthy that in recent years, the prevalence of fatty liver has been on the rise. After B-ultrasound examination, the prevalence is as high as 30%. [0003] Liver diseases are most...
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