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Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases

A technology of dimethylchalcone and methoxy, which is applied in application, food preparation, drug combination, etc., to achieve the effect of reducing AST value, alleviating mouse mania, and reducing ALT value

Inactive Publication Date: 2011-05-25
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (2',4'-dihydroxy-6'-methoxy-3',5' -dimethylchalcone, DMC) for the relevant reports on protecting the liver

Method used

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  • Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases
  • Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone's protective effect on CCl4-induced acute liver cell injury

[0017] Reagents and Drugs:

[0018] ALT (alanine aminotransferase) detection kit, Nanjing Jiancheng Biotechnology Co., Ltd.;

[0019] CCl4 (Shanghai Lingfeng Chemical Reagent Co., Ltd., analytically pure), biphenyl diester (BDP) (Jiangsu Pengyao Pharmaceutical Co., Ltd.), DMSO (Shanghai Chemical Reagent Company, analytically pure), dipotassium hydrogen phosphate and dihydrogen phosphate Potassium is analytically pure;

[0020] DMC, 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone, is extracted and isolated from Hydrangea flower in the laboratory, with a purity of >98% (HPLC) .

[0021] Experimental method and results:

[0022] 1. Hepatocyte isolation and culture

[0023] Select a newborn mouse of about 10 g, fast for 24 hours, decapitate the blood, separate the liver aseptically, weigh it, place it in PBS solution, wash the liver until gray...

Embodiment 2

[0033] Example 2 2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone's protective effect on CCl4-induced acute liver injury in mice

[0034] Reagents and Drugs:

[0035] ALT (alanine aminotransferase) detection kit and AST (aspartate aminotransferase) detection kit were purchased from Nanjing Jiancheng Biotechnology Co., Ltd.;

[0036] CCl4 (Shanghai Lingfeng Chemical Reagent Co., Ltd., analytically pure), biphenyl diester (BDP) (Jiangsu Pengyao Pharmaceutical Co., Ltd.), sodium carboxymethylcellulose (CMC-Na) (Shanghai Sanpu Chemical Co., Ltd., analysis pure); peanut oil (Arowana brand extra virgin peanut oil);

[0037] DMC, 2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone, is extracted and isolated from Hydrangea flower in the laboratory, with a purity of >98% (HPLC) .

[0038] Kunming mice, weighing (25±2) g, male and female, were purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0039] Experimental method and results:

[0040] 60 Kunming mice were rando...

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Abstract

The invention relates to a use of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of liver-protecting medicaments, foods or health care products. The invention further relates to a use of the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in the preparation of the medicaments, the foods or the health care products for treating or preventing liver diseases and complications thereof. The 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone is found to have an obvious protecting role for in vitro liver cell injuries through the research of the invention, and can be used for preparing the liver-protecting medicaments, the foods or the health care products; and the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone further has an obvious repair role for in vivo liver organ injuries, and can be used for preparing the medicaments, the foods or the health care products for treating or preventing liver diseases and the complications thereof, thereby bringing the gospel to patients with the liver diseases and being applicable to large-scale popularization and application.

Description

technical field [0001] The present invention relates to the technical field of application of compounds, in particular to the technical field of application of chalcones, specifically a 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethyl Application of chalcone in preparation of medicine for treating liver diseases. Background technique [0002] my country is an area with a high incidence of liver disease, and hepatitis patients account for more than 10% of the total population. At present, anti-hepatitis drugs commonly used in clinic can be roughly divided into three categories: antiviral drugs, immunomodulatory drugs and hepatoprotective drugs. At present, there are 12 million people in the country suffering from chronic liver disease, and 300,000 people are killed by liver disease every year. It is noteworthy that in recent years, the prevalence of fatty liver has been on the rise. After B-ultrasound examination, the prevalence is as high as 30%. [0003] Liver diseases are most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P1/16A23L1/30A23L33/105
Inventor 卢艳花玉万国路越
Owner EAST CHINA UNIV OF SCI & TECH
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