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Preparation technology of new integrative formulation of pinellia decoction for purging stomach fire and production method thereof

A technology of Banxia Xiexin Decoction and a production method, which are applied in the directions of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., to achieve the effect of wide targeted distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no identical or similar literature reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles. The composition of the raw materials used to make the active ingredients is——

[0043] 9 parts of pinellia, 6 parts of skullcap, 6 parts of dried ginger, 6 parts of ginseng, 6 parts of roasted licorice, 3 parts of berberine, and 4 parts of jujube.

[0044] Its manufacturing process is as follows:

[0045]In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according...

Embodiment 2

[0047] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0048] The composition of the raw materials used to make the active ingredients is——

[0049] 9 parts of pinellia, 6 parts of skullcap, 6 parts of dried ginger, 6 parts of ginseng, 6 parts of roasted licorice, 3 parts of berberine, and 4 parts of jujube.

[0050] Its manufacturing process is as follows:

[0051] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, p...

Embodiment 3

[0053] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion. The composition of the raw materials used to make the active ingredients is——

[0054] 9 parts of pinellia, 6 parts of skullcap, 6 parts of dried ginger, 6 parts of ginseng, 6 parts of roasted licorice, 3 parts of berberine, and 4 parts of jujube.

[0055] Its manufacturing process is as follows:

[0056] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square c...

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Abstract

The invention relates to a preparation technology of a new integrative formulation of pinellia decoction for purging stomach fire and a production method thereof, and the effective components of the raw materials comprises, by weight: 9 parts of pinellia ternate, 6 parts of baikal skullcap roots, 6 parts of dried ginger, 6 parts of ginseng, 6 parts of mix-fried glycyrrhiza, 3 parts of coptis, and 4 parts of jujube. The production method comprises the following steps of extraction by alcohol water, ultrasonic pulverization and extraction, extraction by microwave, water decoction and concentration, spray drying, homogenization under a high pressure, nano-milling, nano-particle preparation, etc. The invention emphasizes the advantages of the stronger synergistic and targeting effects of the nanometer traditional Chinese medicines. After industrial large-scale production, the production cost can be greatly reduced with the product quality being improved, so the targeting effect and the sustained and controlled release of the drugs are stronger. The prepared film agent can be applied on human skin, and the treatment is performed through percutaneous absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Banxia Xiexin Decoction, and also relates to a preparation technology of a new integrated dosage form of Banxia Xiexin Decoction and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatment principles of traditional Chinese medicine treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. What a single ingredient can sum up. The efficacy of the compound medicine is not only related to the active substances or groups of effective substances, but also related to the auxiliary components. When the traditional Chines...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61P1/00A61P1/02A61P1/12A61P1/14A61P1/04A61P7/00A61P11/00A61P13/00A61P15/00A61P37/04
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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