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Process for making gastroretentive dosage forms

A gastroretentive and dosage form technology, which is applied in the field of preparation of gastroretentive dosage forms, can solve the problems of inapplicable active ingredients, inability to provide loading rate, difficult to implement and the like

Inactive Publication Date: 2011-06-22
地中海大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the above technical solutions are not suitable for any type of active ingredients, cannot provide arbitrary loading rates, and are difficult to implement

Method used

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  • Process for making gastroretentive dosage forms
  • Process for making gastroretentive dosage forms
  • Process for making gastroretentive dosage forms

Examples

Experimental program
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Effect test

Embodiment

[0119] Preparation of solid dosage forms according to the invention

[0120]Two different solid dosage forms (100 gram batches) of the following compositions were prepared according to the invention. Dosage Form No. 1 includes a hydrophilic API and Dosage Form No. 2 includes a hydrophobic API. Enlarged pictures of dosage forms No. 1 and No. 2 of the described structure are in image 3 given in.

[0121]

[0122]

77.5％

[0123] The API powder was loaded into a shear mixer 4M8 granulator together with other excipients and mixed at 150 rpm for 2 minutes and 30 seconds. Granulation was initiated by adding water at a rate of 10 ml / min at 1000 rpm. Over-granulation was achieved after introducing 80 ml of water to form a solution:powder ratio of 0.8, and the resulting paste was further kneaded at 1500 rpm for 2 minutes and 30 seconds until it showed 4 to 8% torque resistance. The resulting material is then molded in a paraffin oil lubricat...

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PUM

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Abstract

The present invention relates to a novel process for making oral solid gastro-retentive forms, comprising the steps of providing a powder mixture comprising a hydrophobic powder, overgranulating this powder mixture with a granulating solution into an overgranulated paste, and drying said paste into a solid, as well as to pharmaceutical solid dosage forms which are retained in the stomach or upper gastrointestinal tract for a controlled delivery of a drug.

Description

technical field [0001] The present invention relates to novel pharmaceutical compositions that are retained in the stomach or upper gastrointestinal tract to achieve controlled drug delivery. The invention also provides methods of making these dosage forms and methods of using these dosage forms in therapy. Background technique [0002] The efficacy of therapeutic agents is closely related to their method of administration. When taken orally, drugs interact with specific absorption sites located at different points throughout the gastrointestinal (GI) tract, resulting in certain agents being absorbed only in the stomach, upper or lower intestinal tract. Therefore, because these drugs are not absorbed uniformly throughout the length of the gastrointestinal tract, the rate of absorption is not constant, and the most effective treatment cannot be performed. These can be significantly improved when the method of administration provides controlled delivery of the active ingredi...

Claims

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Application Information

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IPC IPC(8): A61K9/20
CPCA61K9/0065
Inventor 帕斯卡尔・普兰德尔克里斯托夫・索泽
Owner 地中海大学
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