Ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and microbubble breakage evaluation method

Abstract

The invention discloses an ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and a microbubble breakage evaluation method. In the ultrasonic contrast monitor imaging method, a local, fixed-point and conformal control release function and a low-energy coded excitation monitor imaging function of medicament-carried ultrasonic contrast encapsulated microbubbles are realized on the conventional fully digital ultrasonic imaging system, so that working modes and the functions of the conventional fully digital diagnostic ultrasonic equipment are substantially extended. The local, fixed-point and conformal control release method of the medicament-carried ultrasonic contrast encapsulated microbubbles is firstly developed on the conventional fully digital ultrasonic imaging system; then the medicament-carried contrast microbubbles of a lesion region before and after medicament release are monitored by a low-energy coded excitation monitor imaging method; and finally, a method for evaluating medicament release capacity based on radio frequency echo data of the monitor imaging and variation in scatterer concentration of a region of interest is developed.

Description

technical field [0001] The invention belongs to the field of ultrasonic diagnosis and treatment, and in particular relates to an ultrasonically controlled release of drug-loaded contrast microbubbles, a monitoring imaging method and a microbubble damage evaluation method, which expands the functions of the existing fully digital ultrasonic imaging system to both It has two functions of local, fixed-point, conformal spatio-temporal control release of drug-carrying ultrasound contrast-enhanced encapsulated microbubbles (hereinafter referred to as drug-loaded contrast microbubbles) and low-energy coding excitation monitoring imaging. Background technique [0002] The drug release system is to encapsulate the drug in the carrier, implant or inject into the body, and achieve the release of the drug through the slow degradation of the carrier in the body or the induction method of exogenous stimulation, and increase the drug concentration in the local lesion tissue. In recent year...

AI Technical Summary

Problems solved by technology

From the perspective of ultrasonic drug controlled release technology, the drug release caused by the breakage of drug-loaded microbubbles in the scanning beam of a single ultrasonic probe or on the imaging plane of B-mode scanning in traditional mode is uncontrollable release, which cannot be achieved at a fixed point in space. Requirements for local and conformal release

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