Ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and microbubble breakage evaluation method

A technology of ultrasonic control and imaging method, which is applied in the fields of drug devices, ultrasonic/sonic/infrasonic diagnosis, medical science, etc. energy boosting effect

Inactive Publication Date: 2011-07-06
XI AN JIAOTONG UNIV
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the perspective of ultrasonic drug controlled release technology, the drug release caused by the breakage of drug-loaded microbubbles in the scanning beam of a single ultrasonic probe

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and microbubble breakage evaluation method
  • Ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and microbubble breakage evaluation method
  • Ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and microbubble breakage evaluation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] The present invention mainly comprises following three contents:

[0036] The first aspect is to provide a system solution that expands the original single diagnostic imaging function of the fully digital ultrasound imaging system into a system solution with local, fixed-point, conformal control release of drug-loaded contrast microbubbles and low-energy coding excitation monitoring imaging functions;

[0037] The second aspect is to develop a technology of conformal focal domain inverse synthesis control for local and fixed-point drug release control on the existing fully digital ultrasound imaging system;

[0038] In the third aspect, a method for evaluating the amount of drug destruction in the region of interest based on the parameter m in the Nakagami statistical model is provided;

[0039] The more specific technical solutions and implementation methods of the above three aspects are described in detail below:

[0040]The present invention provides a system solut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an ultrasonic control release and monitor imaging method for medicament-carried contrast microbubbles and a microbubble breakage evaluation method. In the ultrasonic contrast monitor imaging method, a local, fixed-point and conformal control release function and a low-energy coded excitation monitor imaging function of medicament-carried ultrasonic contrast encapsulated microbubbles are realized on the conventional fully digital ultrasonic imaging system, so that working modes and the functions of the conventional fully digital diagnostic ultrasonic equipment are substantially extended. The local, fixed-point and conformal control release method of the medicament-carried ultrasonic contrast encapsulated microbubbles is firstly developed on the conventional fully digital ultrasonic imaging system; then the medicament-carried contrast microbubbles of a lesion region before and after medicament release are monitored by a low-energy coded excitation monitor imaging method; and finally, a method for evaluating medicament release capacity based on radio frequency echo data of the monitor imaging and variation in scatterer concentration of a region of interest is developed.

Description

technical field [0001] The invention belongs to the field of ultrasonic diagnosis and treatment, and in particular relates to an ultrasonically controlled release of drug-loaded contrast microbubbles, a monitoring imaging method and a microbubble damage evaluation method, which expands the functions of the existing fully digital ultrasonic imaging system to both It has two functions of local, fixed-point, conformal spatio-temporal control release of drug-carrying ultrasound contrast-enhanced encapsulated microbubbles (hereinafter referred to as drug-loaded contrast microbubbles) and low-energy coding excitation monitoring imaging. Background technique [0002] The drug release system is to encapsulate the drug in the carrier, implant or inject into the body, and achieve the release of the drug through the slow degradation of the carrier in the body or the induction method of exogenous stimulation, and increase the drug concentration in the local lesion tissue. In recent year...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61B8/00A61M37/00
Inventor 万明习徐姗姗徐志安宗瑜瑾
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap