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4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone in loropetalum leaves and application thereof

A technology of dimethylbutyl and methoxyphenyl, which is applied in the separation/purification of ketones, carbonyl compounds, skin diseases, etc., can solve the problems that have not been reported in the literature, and achieve a clear and easy-to-use material basis. Accepted and beneficial to the effect of exporting foreign exchange

Inactive Publication Date: 2011-07-27
湖南本草制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone in loropetalum leaves and application thereof
  • 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone in loropetalum leaves and application thereof
  • 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone in loropetalum leaves and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Take 200kg of loropetalum leaves, add 90% ethanol to reflux and extract twice, each time for 1 hour, add 1000kg90% ethanol for the first time, add 800kg90% ethanol for the second time, filter, combine the extracts, and recover ethanol from the extracts and concentrated to a dilute extract with a relative density of 1.05, pass the dilute extract through D101 macroporous adsorption resin, first elute with 30% ethanol until colorless, discard the 30% ethanol eluate, and then use 90% ethanol The ethanol was eluted to colorless, and the 90% ethanol eluate was collected, and the ethanol was recovered to obtain the extract. The extract was mixed with silica gel and added to a silica gel column, chloroform-methanol gradient elution, the eluate was collected, identified by thin-layer chromatography, combined, passed through a SephadexLH-20 gel column, and eluted with methanol. Collect eluate, identify by thin layer chromatography, combine, recover methanol, pass through RP-18 re...

Embodiment 2

[0028] Take the 4-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2,3-dimethylbutyl-1-one and add it in a ratio of 1:2 Dextrin, mixed evenly, adopts the existing hard capsule preparation process to obtain 4-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2,3-dimethyl The drug in the form of hard capsules of butyl-1-one.

Embodiment 3

[0030] Take the 4-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2,3-dimethylbutyl-1-one and add it in a ratio of 1:3 Vegetable oil, mixed evenly, using gelatin as the capsule shell material, adopting the existing soft capsule preparation process to obtain 4-(4-hydroxyl-3-methoxyphenyl)-1-(4-hydroxyphenyl)- 2,3-Dimethylbutyl-1-one is a drug in the form of soft capsules.

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Abstract

The invention discloses 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone extracted from traditional Chinese medicine, Loropetalum leaves, and further discloses the medical application of the 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone in treating burning, scalding and trauma. Proved by experiment, the 4-(4-hydroxy-3-methoxyphenyl)-1-(4-phenyl)-2, 3-dimethyl butyl-1-ketone has obvious function of inhibiting nitric oxide release of mouse macrophage sample cell strain RAW264.7 and antibacterial activity.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to 4-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2,3-dimethylbutanol extracted from the leaves of the traditional Chinese medicine Loropetalum Base-1-ketone and the medical application of this compound. Background technique [0002] Burns, sunburn and trauma are common diseases, with an incidence rate of about 2%, and the market demand for their therapeutic drugs has great potential. At present, clinical treatment methods are mainly divided into surgical treatment and conservative treatment. Some oils and ointments are commonly used in domestic conservative treatment, all of which have the disadvantages of unclear active ingredients and unclear material basis for action. The market still lacks high-efficiency, low-toxicity and effective Drugs with a clear material basis. [0003] Loropetalum chinense (R.Br.) Oliv., a traditional Chinese medicine, is recorded ...

Claims

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Application Information

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IPC IPC(8): C07C49/84C07C45/79A61K31/12A61P17/02
Inventor 李雪松周小江
Owner 湖南本草制药有限责任公司
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