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Electrochemical sensor chip with digital microfluidic technology

A digital microfluidic and electrochemical technology, applied in scientific instruments, instruments, material analysis by electromagnetic means, etc., can solve problems such as the limitation of the sensitivity of the detection system, and achieve the effect of increasing the detection sensitivity

Inactive Publication Date: 2011-09-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This will bring great limitations to further improve the sensitivity of the detection system

Method used

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  • Electrochemical sensor chip with digital microfluidic technology
  • Electrochemical sensor chip with digital microfluidic technology
  • Electrochemical sensor chip with digital microfluidic technology

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Embodiment Construction

[0022] The following is based on figure 1 — image 3 A preferred embodiment of the present invention is given and described in detail in order to better illustrate the present invention but not to limit the scope of the present invention.

[0023] according to figure 1 Shown, the concrete implementation step of the present invention is as follows:

[0024] Droplet Control Unit:

[0025] 1) Preparation of substrate 1

[0026] The substrate 1 can be any material, including a flexible substrate. If the substrate is a conductive material, an insulating layer 2 should be deposited first, and the process of depositing the insulating layer can be thermal oxidation, chemical vapor deposition CVD or physical vapor deposition PVD and other processes. For example, if the substrate is made of silicon, an insulating layer of silicon dioxide can be used.

[0027] 2) Deposition and patterning of the electrode layer 3 .

[0028] The electrode 3 can be metal, conductive polymer or condu...

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Abstract

The invention belongs to the technical field of biological chips, concretely relates to a novel electrochemical sensor chip with a digital microfluidic technology. The chip is sequentially composed of three parts from bottom to top: a droplet control unit, a droplet passage and an electrochemical unit, wherein the droplet control unit is composed of a first substrate, a first insulation layer, a first electrode layer, a second insulation layer and a first hydrophobic layer from bottom to top; the electrochemical unit is sequentially composed of an electrochemical electrode group, a second hydrophobic layer, a second electrode layer, a third insulation layer and a second substrate from bottom to top; when the first substrate and the second substrate are insulation materials, the first insulation layer and the third insulation layer are left out; the electrochemical electrode group comprises a counter electrode, a working electrode and a reference electrode and covers the lower surface of the second hydrophobic layer; the droplet passage is an air gap in the droplet control unit and the electrochemical unit. In the invention, the advantages of a digital microfluidic technology and an electrochemical sensor technology are combined and a novel micro-analysis device is provided for biochemical analysis; and therefore, the sample demand is decreased, the detection speed is increased, the conveying of various liquid samples needed in detection can be realized and the on-line detection is realized.

Description

technical field [0001] The invention belongs to the technical field of biological chips, and in particular relates to an electrochemical sensor chip of digital microfluidic technology. Background technique [0002] Integrated chips based on microfluidic technology and electrochemical detection are currently very hot research areas. This integrated chip can make full use of the advantages of micro-processing and integration technology and combine various analysis and detection principles to realize a micro-miniature analytical instrument, which has the advantages of small size, low power consumption, high sensitivity, and portability, and can be widely used in biological , medical and chemical detection, and has application potential in national security, immune detection, environmental protection, food hygiene, genetic screening, disease diagnosis and other fields. [0003] The electrochemical detection method is a technology to study the relationship between electrical and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416
Inventor 杨盛曾祥宇周嘉
Owner FUDAN UNIV
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