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Liquid preparation of sodium ascorbyl phosphate

A technology of liquid preparation and sodium phosphate salt, which is applied in the direction of active ingredients of phosphorus compounds, drug delivery, digestive system, etc., and can solve problems such as high equipment and energy consumption, and inconvenience in industrialization

Active Publication Date: 2011-09-14
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is sterilized by high temperature, which requires a lot of equipment and energy consumption in production, which brings a lot of inconvenience to industrialization

Method used

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  • Liquid preparation of sodium ascorbyl phosphate
  • Liquid preparation of sodium ascorbyl phosphate
  • Liquid preparation of sodium ascorbyl phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] prescription:

[0018]

[0019] Preparation Process:

[0020] (1) Dosing: First, stir and dissolve the prescribed amount of benzalkonium chloride and EDTA-2Na with 70% purified water, then add Na 2 HPO 4 ·7H 2 O and NaH 2 PO 4 ·H 2 O, stir to dissolve, add purified water to the full amount, stir and mix evenly to obtain the original solution before filtration, take a sample to detect the intermediate pH, relative density and content;

[0021] (2) Filtration: After the intermediate is qualified, filter the solution with a 0.45 μm microporous membrane;

[0022] (3) Filling and sealing: prepare plastic bottles and fill them. After filling, seal and cap in time, and send samples for inspection;

[0023] (4) Packing: After the samples are fully inspected after filling, the qualified products will be labeled and packed into cartons.

Embodiment 2

[0025] prescription:

[0026]

[0027] Preparation Process:

[0028] (1) Dosing: First, stir and dissolve the prescribed amount of benzalkonium chloride and EDTA-2Na with 70% purified water, then add Na 2 HPO 4 ·7H 2 O and NaH 2 PO 4 ·H 2 O, stir to dissolve, add purified water to the full amount, stir and mix evenly to obtain the original solution before filtration, take a sample to detect the intermediate pH, relative density and content;

[0029] (2) Filtration: After the intermediate is qualified, filter the solution with a 0.45 μm microporous membrane;

[0030] (3) Filling and sealing: prepare plastic bottles and fill them. After filling, seal and cap in time, and send samples for inspection;

[0031] (4) Packing: After the samples are fully inspected after filling, the qualified products will be labeled and packed into cartons.

Embodiment 3

[0033] prescription:

[0034]

[0035] Preparation Process:

[0036] (1) Dosing: First, stir and dissolve the prescribed amount of benzalkonium chloride and EDTA-2Na with 70% purified water, then add Na 2 HPO 4 ·7H 2 O and NaH 2 PO 4 ·H 2 O, stir to dissolve, add purified water to the full amount, stir and mix evenly to obtain the original solution before filtration, take a sample to detect the intermediate pH, relative density and content;

[0037] (2) Filtration: After the intermediate is qualified, filter the solution with a 0.45 μm microporous membrane;

[0038] (3) Filling and sealing: prepare plastic bottles and fill them. After filling, seal and cap in time, and send samples for inspection;

[0039] (4) Packing: After the samples are fully inspected after filling, the qualified products will be labeled and packed into cartons.

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PUM

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Abstract

The invention discloses a liquid preparation of sodium ascorbyl phosphate. Each 1,000 milliliters of liquid preparation contains 40 to 180 grams of Na2HPO4.7H2O, 100 to 480 grams of NaH2PO4.H2O, and 0.05 to 0.3 grams of preservative. The liquid preparation of the sodium ascorbyl phosphate has a remarkable preservative effect; and the solubility, dissolution speed and stability of the sodium ascorbyl phosphate, which is the mixture of the Na2HPO4.7H2O and NaH2PO4.H2O, are high.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition, in particular to a sodium phosphate salt liquid preparation and a preparation method thereof. Background technique [0002] Sodium phosphate salt is used for colon X-ray and intestinal endoscopy or to clean up the intestinal tract before surgery. Sodium phosphate salt dissociates unabsorbed anions and cations in the intestinal tract, forming a hypertonic environment in the intestinal tract. The nature of the semi-permeable membrane allows water in the body to enter the intestinal tract, and the water contained in itself and the water taken by the patient jointly produce a mechanical stimulus to promote intestinal movement. Sodium phosphate increases the water content in the intestine and softens the stool. Sodium phosphate can also activate the local nerve reflex of the intestinal mucosa to increase the peristalsis of the intestinal wall, imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/08A61P1/10
Inventor 王国华杜作宽梅勇刘萍赵小萍杨勇万华英
Owner 四川健能制药有限公司
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