Low total salt reagent compositions and systems for biosensors

Abstract

A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w / w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one &Dgr;S value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one &Dgr;S value, where the compensation equation has a R2 value of at least 0.5.

Description

[0001] References to related applications [0002] This application claims priority to US Provisional Application No. 61 / 201,242, entitled "Low-Salt Reagent Composition," filed December 8, 2008, which is hereby incorporated by reference in its entirety. Background technique [0003] Biosensors provide analysis of biological fluids such as whole blood, serum, plasma, urine, saliva, interstitial or intracellular fluids. Typically, a biosensor has a measurement device for analyzing a sample deposited on the test sensor. The sample is usually liquid and may be a biological fluid or a derivative of a biological fluid, such as an extract, dilution, filtrate or reconstituted precipitate. Analysis performed by biosensors determines the presence and / or concentration of one or more analytes in a biological fluid. Examples of analytes include alcohol, glucose, uric acid, lactate, cholesterol, bilirubin, free fatty acids, triglycerides, proteins, ketones, phenylalanine, or enzymes. Suc...

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Problems solved by technology

In these systems, any glucose measurement made on a blood sample containing less than or greater than 40% hematocrit will include error and thus have a bias due to the hematocrit effect

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