Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient

A technology of active ingredients and compositions, applied in the field of wrinkle-improving skin cosmetic compositions containing edelweiss acid as an active ingredient, can solve problems such as skin side effects, reduce normal skin functions, and unsatisfactory effects, and achieve dosage form stability Excellent skin absorption ability, improved collagenase expression inhibition effect, and excellent promotion effect

Active Publication Date: 2014-07-30
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive physical stimulation, chemical stimulation, fatigue, and lack of nutrition from the outside will reduce the normal function of the skin and promote skin aging such as loss of elasticity, keratinization, and wrinkles. In order to prevent these phenomena and maintain health Most of the currently used cosmetics have many problems such as unsatisfactory effects or skin side effects.

Method used

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  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient
  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient
  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] [Example 1] Production of edeltoxin

[0051] The extract of Edelweiss alpina (2 kg) dried in a cool place at room temperature was collected by repeated cold soaking with methanol three times every week, and concentrated under reduced pressure to obtain 160.5 g of methanol extract. The methanol extract was suspended in distilled water and partitioned with hexane (25.2g), then the remaining aqueous layer was re-divided with ethyl acetate to obtain an acetonitrile fraction (20.4g), and then the remaining aqueous layer was re-divided with butanol And get the butanol extract (20.6g) and finally get 40.6g of water.

[0052] Then, use methanol to dissolve 40.6 g of the above-mentioned water containing surface materials and use a glass column filled with silica gel ( 7734, Merck Corporation) and a mixed solvent of water, acetonitrile, and methanol to dissolve the active material to obtain 10 subdivisions. Among them, the sub-hollow column chromatography analysis was carried out on...

Embodiment 2

[0053] [Example 2] Production of leontoxic acid stabilized into nanoliposomes

[0054] In order to stabilize the above-mentioned leontoic acid into nanoliposomes, 580 g of glycerol, 200 g of caprylic capric triglyceride, 50 g of phospholipids, and 20 g of cholesterol were mixed with a blender and heated to 75°C. After mixing and dissolving, add from the above example 1 Obtain 50g of edelontoic acid solid powder and dissolve it completely. Here, 100 g of purified water was slowly added, mixed, and passed through a three-time high-pressure softening device (Microfluidizer M210EH, Microfluidics, USA) 3 under the adjustment of a pressure of 1000 mbar at 50° C. to prepare nanoliposomes of leonoronic acid. The particle size of the liposome is about 70 nm.

experiment example 1

[0055] [Experimental example 1] Testing the promoting effect of collagen biosynthesis

[0056] Compare with a tocopherol and EGCG that can promote collagen biosynthesis to test the collagen biosynthesis promoting effect of Example 1 above.

[0057] First, seed 10 in each of the 24 wells (well) 5 Personal fibroblasts (PromoCell, Germany) were cultured to 90%. Then it was cultured in serum-free DMEM medium for 24 hours, and the tocopherol and EGCG of Example 1, which were melted in serum-free medium, were treated at 10-4 molar concentrations and treated in CO 2 Cultivate for 24 hours in the incubator. Salvage the upper layer of these liquids and use the procollagen type (I) enzyme-linked immunosorbent assay (ELISA) tool (procollagen type (I)) to check whether the procollagen (procollagen) increases or decreases. The results are shown in Table 1 below. Here, the synthesis ability is compared with the non-treatment group being 100.

[0058] 【Table 1】

[0059] Processing group

[0060...

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Abstract

The present invention discloses a wrinkle-improving skin cosmetic composition containing leontopodic acid as an active ingredient, which exhibits enhanced collagenase expression inhibition effect, collagen biosynthesis promotion effect, and wrinkle improvement Effect skin cosmetic composition. Also disclosed is a skin cosmetic composition for wrinkle improvement containing edelweiss acid stabilized into nano liposomes, which has excellent dosage form stability and hard skin absorbability.

Description

Technical field [0001] The present invention relates to a method which contains leontopodic acid {Leontopodicacid; 2-[(3S)-3-hydroxybutanate]-3,4,5-tris-[(2E)-3-( as an active ingredient represented by the following chemical formula 1 3,4-dihydroxyphenyl)-2-propenoate]-D-glucaricacid} skin cosmetic composition for improving wrinkles. [0002] 【Chemical formula 1】 [0003] Background technique [0004] The skin is the human body's first protective film. It protects various organs in the body from external environmental stimuli such as temperature and humidity changes, ultraviolet rays, and pollution substances, and plays an important role in the process of maintaining the constancy of the organism such as regulating body temperature. However, excessive physical stimulation, chemical stimulation, fatigue, lack of nutrition, etc. received from the outside will reduce the normal function of the skin, and promote skin aging such as loss of elasticity, keratinization, and wrinkles. In o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/35A61Q19/08
CPCA61K8/14A61Q19/08A61K8/375A61K8/55A61K8/66A61Q19/00A61Q19/02
Inventor 金汉星安顺爱金德姬金真雄金汉坤
Owner AMOREPACIFIC CORP
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