Benidipine hydrochloride dispersing tablet and preparation method thereof
A technology of benidipine hydrochloride and benidipine hydrochloride is applied in the field of benidipine hydrochloride dispersible tablets and their preparation, which can solve the problems of long tablet disintegration time, low bioavailability, single taking method and the like, and achieve rapid drug dissolution , the effect of high bioavailability and simple production process
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Embodiment 1
[0032] The formula of dispersible tablets is composed of: benidipine hydrochloride 2g, microcrystalline cellulose 20g, lactose 10, pregelatinized starch 25g, super starch sodium 16g, croscarmellose sodium 23g, hypromellose 1g, Aspartame 0.5g, magnesium stearate 0.2g.
[0033] Take benidipine hydrochloride, microcrystalline cellulose, lactose, pregelatinized starch, super carmellose sodium starch, croscarmellose sodium, hypromellose, and aspartame according to the formula, sieve, mix well, Use an appropriate amount of 50% ethanol solution to make soft material, pass through a 18-mesh sieve to granulate, dry at 50°C for 4 hours, granulate through a 18-mesh sieve, add magnesium stearate, mix evenly, and press into tablets, weighing 0.1g.
Embodiment 2
[0035] The formula of dispersible tablets is composed of: benidipine hydrochloride 2g, microcrystalline cellulose 30g, lactose 15g, sodium starch glycolate 30g, croscarmellose sodium 19g, hypromellose 2g, sodium saccharin 1g, stearic acid Magnesium 1g.
[0036] Take benidipine hydrochloride, microcrystalline cellulose, lactose, carboxymethyl starch sodium, croscarmellose sodium, hypromellose, and saccharin sodium according to the formula, sieve, mix well, and use an appropriate amount of 60% ethanol solution to soften Material, passed through a 20-mesh sieve to granulate, dried at 60°C for 4 hours, granulated through a 20-mesh sieve, added magnesium stearate, mixed evenly, and pressed into tablets.
Embodiment 3
[0038] The formula of the dispersible tablet consists of: benidipine hydrochloride 2g, microcrystalline cellulose 20g, pregelatinized starch 44g, crospovidone 50g, hypromellose 3g, povidone K30 1g, aspartame 4g, Magnesium stearate 2g.
[0039] Take benidipine hydrochloride, microcrystalline cellulose, pregelatinized starch, crospovidone, hypromellose, povidone K30, and aspartame according to the formula, sieve, mix well, and add an appropriate amount of 75% ethanol Soft material made from solution, passed through a 20-mesh sieve to granulate, dried at 65°C for 4 hours, granulated through a 20-mesh sieve, added magnesium stearate, mixed evenly, and compressed into tablets.
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