Differential expression profile model of hepatitis B virus (HBV) infectivity and alcoholic cirrhosis, and construction method thereof

Abstract

The invention relates to a construction method for a differential expression profile model of hepatitis B virus (HBV) infectivity and alcoholic cirrhosis. According to the method, peripheral blood samples of liver cirrhosis patients with HBV infections, alcoholic cirrhosis patients and healthy people are sampled to carry out nulcear magnetic resonance analysis, then a multi-variable statistical analysis is adopted for the resulting spectrograms from the nulcear magnetic resonance analysis to obtain the differential expression profile model of the HBV infectivity and the alcoholic cirrhosis. According to the present invention, the metabonomics analysis method is adopted for analyzing the metabolic products of the liver cirrhosis patients with HBV infections, the alcoholic cirrhosis patients and the healthy people, such that the specific metabolic products related to the pathologic mechanisms of the liver cirrhosis with the HBV infection and the alcoholic cirrhosis are found, the differential expression profile model of the HBV infectivity and the alcoholic cirrhosis is constructed; such that a support is provided for specific diagnosis and treatment of the liver cirrhosis with the HBV infection and the alcoholic cirrhosis. In addition, the invention further relates to a differential expression profile model of the HBV infectivity and the alcoholic cirrhosis.

Description

【Technical field】 [0001] The invention relates to a differential expression map model of HBV-infected liver cirrhosis and alcoholic liver cirrhosis and a construction method thereof. 【Background technique】 [0002] Metabolomics, as an emerging systems biology technology, dynamically tracks and monitors the overall composition of small molecular metabolites (generally referring to low-molecular compounds with a relative molecular weight less than 1000) in body fluids and tissues, combined with pattern recognition. Variable statistical analysis method to detect and analyze the changes of endogenous metabolites when the body is subjected to environmental and pathological stimuli. The techniques commonly used in metabolomics include nuclear magnetic resonance (nuclear magnetic resonance, NMR) and mass spectrometry (mass spectrometry, MS). and 1 Due to its advantages of less damage, high repeatability and unbiasedness, H NMR has made metabolomics technology widely used in clini...

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Problems solved by technology

However, there are few traditional studies on the pathogenesis of HBV-infected cirrhosis and alcoholic

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