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Quetiapine fumarate sustained-release tablets and preparation method thereof

A technology of quetiapine fumarate and quinoline fumarate, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the complex preparation process, environmental and human hazards. and irritation, etc., to achieve the effect of simple process and good sustained release performance

Inactive Publication Date: 2012-02-01
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the waxy material cetyl alcohol used in the above-mentioned patents is harmful and irritating to the environment and the human body, and the preparation process is relatively complicated.

Method used

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  • Quetiapine fumarate sustained-release tablets and preparation method thereof
  • Quetiapine fumarate sustained-release tablets and preparation method thereof
  • Quetiapine fumarate sustained-release tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of Quetiapine Fumarate Sustained Release Tablets

[0033] Take 200g of quetiapine fumarate (calculated as quetiapine) and crush it, pass it through an 80-mesh sieve, and mix it with 58g acrylic resin RL PO, and use 9g 10% polyvinylpyrrolidone K-30 as a soft material as a binder; Granulate with an 18-mesh sieve, dry, use an 18-mesh sieve to sizing, add 3 g of magnesium stearate, mix well, and compress.

Embodiment 2

[0034] Example 2: Preparation of Quetiapine Fumarate Sustained Release Tablets

[0035] Take 200g of quetiapine fumarate (calculated as quetiapine) and crush it, pass it through an 80-mesh sieve, and mix it with 58g of acrylic resin RS PO, and use 9g of 10% polyvinylpyrrolidone K-30 as a binder to make a soft material; Granulate with an 18-mesh sieve, dry, use an 18-mesh sieve to sizing, add 3 g of magnesium stearate, mix well, and compress.

Embodiment 3

[0036] Example 3: Preparation of Quetiapine Fumarate Sustained Release Tablets

[0037] Take 200g of quetiapine fumarate (calculated as quetiapine), crush it, pass through an 80-mesh sieve, and mix with 29g acrylic resin RL PO and 29g acrylic resin RS PO, and use 9g 10% polyvinylpyrrolidone K-30 as the adhesive Preparation of soft material; granulate through an 18-mesh sieve, dry, sizing with an 18-mesh sieve, add 3g of magnesium stearate, mix well, and compress.

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Abstract

The invention belongs to the field of medicinal preparations, and discloses quetiapine fumarate sustained-release tablets and a preparation method thereof. The sustained-release tablets are mainly prepared from the following raw materials in part by mass: 1 part of quetiapine fumarate (based on quetiapine), 0.1 to 1 part of acrylic resin framework material, 0 to 0.5 part of filling agent, 0.04 to0.05 part of adhesive and 0.01 to 0.02 part of lubricating agent. The sustained-release tablets can comprise hydrophilic gel framework material for adjusting the release rate of the main medicament, and the mass ratio of the quetiapine to the hydrophilic gel framework material is 1: (0.1-0.5). The prepared quetiapine fumarate sustained-release tablets can be used for treating schizophrenia. The sustained-release tablets have the advantages of reducing the administration frequency, improving the administration compliance of a patient, improving the medicinal effect, ensuring application safetyand the like, and are more suitable for patients. Meanwhile, the preparation method of the sustained-release tablets is simple and favorable for industrialized large-scale production.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a quetiapine fumarate sustained-release tablet and a preparation method thereof. Background technique [0002] Schizophrenia is a kind of psychiatric disease. It is a continuous and usually chronic major mental illness. It is the most serious type of mental illness. It is based on the division of basic personality, thinking, emotion, and behavior, and the difference between mental activities and the environment. Coordination is one of the most common types of mental illness, which affects behavior and emotion in many young adults. The cause has not yet been fully elucidated. The course of schizophrenia is mostly protracted and progressing. If it is detected early, reasonable treatment should be given as soon as possible. The prognosis of most patients is relatively optimistic. A small number of patients have delayed treatment due to untimely and unreaso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/554A61K47/32A61K47/38A61P25/18
Inventor 曹青日刘妍崔京浩
Owner SUZHOU UNIV
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