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Propionibacterium acnes protein with immune protection function and application of coding genes of Propionibacterium acnes protein

A technology for the protection of Propionibacterium acnes, applied in the fields of application, gene therapy, genetic engineering, etc., can solve the problems of prevention difficulties and restrictions on the development and research of multivalent vaccines, and achieve the effect of broad application prospects

Inactive Publication Date: 2012-02-01
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of effective cross-immune protection among the main serotypes, the development and research of multivalent vaccines are seriously restricted, thus making the prevention of this disease very difficult

Method used

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  • Propionibacterium acnes protein with immune protection function and application of coding genes of Propionibacterium acnes protein
  • Propionibacterium acnes protein with immune protection function and application of coding genes of Propionibacterium acnes protein

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Embodiment Construction

[0020] The heterologous protein of Propionibacterium acnes with immune protection function provided by the present invention is one of the following amino acid residue sequences (the amino acid residue sequence is derived from Propionibacterium acnes isolate S14): SEQ ID NO: 1 (PA3 -SSDB), SEQ ID NO: 2 (PA4-PSPA), SEQ ID NO: 3 (PA6-GAPDH), SEQ ID NO: 4 (PA7-PK), SEQ ID NO: 5 (PA7-SHMT), the SEQ ID NO: 6 (PA7-AST);

[0021] SEQ ID NO: 1 consists of 185 amino acid residues. SEQ ID NO: 2 consists of 268 amino acid residues. SEQ ID NO: 3 consists of 336 amino acid residues. SEQ ID NO: 4 consists of 478 amino acid residues. SEQ ID NO: 5 consists of 492 amino acid residues. SEQ ID NO: 6 consists of 371 amino acid residues.

[0022] The gene encoding the above-mentioned Propionibacterium acnes protein with heterologous immune protection function is one of the following nucleotide sequences: SEQ ID NO: 7 (PA3-SSDB), SEQ ID NO: 8 (PA4-PSPA), SEQ ID NO: 8 (PA4-PSPA), ID NO: 9 (PA6...

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Abstract

The invention relates to a Propionibacterium acnes protein with an immune protection function and an application of coding genes of the Propionibacterium acnes protein, belonging to the biotechnology field. The invention aims to provide a Propionibacterium acnes protein (with an immune protection function) which can excite the specific immune response in the infection and immune process of Actinobacillus pleuropneumoniae, and can generate an immune protection function of a heterologous protein and an application of coding gene of the Propionibacterium acnes protein. The nucleotide sequences of the genes of the Propionibacterium acnes protein with an immune protection function in the invention are as follows: SEQIDNO:1,SEQIDNO:2,SEQIDNO:3,SEQIDNO:4,SEQIDNO:5 and SEQIDNO:6. The protein in the invention can excite the specific immune response in the infection and immune process of Actinobacillus pleuropneumoniae and can generate an immune protection function. The protein or gene in the invention can be used as an active ingredient to prepare an Actinobacillus pleuropneumoniae vaccine. The invention provides a new method for searching the protein (with an immune protection function) of the ctinobacillus pleuropneumoniae, is to play an important role in preventing and treating Infectious Pleuropneumonia of Swine and has a wide prospect.

Description

technical field [0001] The invention belongs to the field of biotechnology. Background technique [0002] Porcine infectious pleuropneumonia is caused by Actinobacillus ( A. pleuropneumoniae ) infection is a highly contagious and fatal respiratory infectious disease of pigs. It was reported for the first time by British Pattison etc. in 1957, and it has been widely popular all over the world in the 1980s. In recent years, it has been internationally recognized as one of the important infectious diseases that endanger the modern pig industry. It is listed as one of the main pig diseases in the United States, Denmark, and Switzerland. With the development of scale and intensification of aquaculture, the occurrence of this disease is in an explosive trend, and the harm to the aquaculture industry is becoming more and more serious. The morbidity rate varies depending on the management and preventive measures taken in various places, but it is generally high (8.5%-100%), and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/31C12N15/63C12N5/10C12N1/15C12N1/19C12N1/21C07K14/195A61K39/02A61K48/00A61P31/04
Inventor 雷连成李林溪韩文瑜杜崇涛孙长江冯新
Owner JILIN UNIV
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