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Sulfuric acid cefquinome frozen powder injection and preparation method thereof

A technology of cefquinol sulfate and freeze-dried powder injection, which is applied in the direction of freeze-drying transportation, powder transportation, pharmaceutical formulations, etc., can solve the problems of low activity of cefquinol sulfate, affecting industrial production, and slow filtration and sterilization speed. Improving animal welfare, reducing the number of injections, and good stability

Active Publication Date: 2012-02-15
JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the instability of the above-mentioned cefquinol sulfate injection, the low activity of cefquinol sulfate in the existing cefquinol sulfate freeze-dried powder injection, and the slow rate of filtration and sterilization, affecting industrial production and other problems, the purpose of the present invention is to provide a Freeze-dried powder injection of cefquinol sulfate with high activity and good stability

Method used

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  • Sulfuric acid cefquinome frozen powder injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0016] The preparation of embodiment 1 cefquinol sulfate freeze-dried powder injection

[0017] Take 100g of hydroxypropyl-β-cyclodextrin, add 100mL of water for injection, stir until clarified; then add 44.4g of cefquinol sulfate, stir until clarified; Dilute to 200mL, dispense into 2mL / bottle, vacuum freeze-dry, and seal.

Embodiment 2

[0018] Example 2 Preparation of cefquinol sulfate freeze-dried powder injection

[0019] Take 200g of cyclodextrin, add 200mL of water for injection, stir until clear; then add 44.4g of cefquinol sulfate, stir until clear; then add 80g of mannitol, mix, filter through a 0.45μm filter membrane, and dilute to 400mL with water for injection, Aliquoted, 2mL / bottle, vacuum freeze-dried, sealed.

Embodiment 3

[0020] Example 3 Preparation of cefquinol sulfate freeze-dried powder injection

[0021] Take 300g of hydroxypropyl-β-cyclodextrin, add 400mL of water for injection, and stir until clear; then add 66.7g of cefquinol sulfate, stir until clear; then add 80g of mannitol and 40g of lactose, mix, and filter through a 0.45μm membrane Filter, dilute to 600mL with water for injection, subpackage, 2mL / bottle, vacuum freeze-dry, seal.

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Abstract

The invention discloses a sulfuric acid cefquinome frozen powder injection, belonging to the field of veterinary drug preparation. The frozen powder injection comprises the ingredients of, by weight, 2.22-6.67 parts of sulfuric acid cefquinome, 5-20 parts of enveloping auxiliary material, 2-10 parts of freeze-dried excipient and the balance of injection water; wherein the weight ratio of the sulfuric acid cefquinome and the injection water is 1:5-20. The invention further discloses a preparation method of the sulfuric acid cefquinome frozen powder injection. Firstly, the sulfuric acid cefquinome frozen powder injection disclosed by the invention has good stability and high activity, and the appearance and the activity barely change after the sulfuric acid cefquinome frozen powder injection is laid aside for six months. Secondly, the sulfuric acid cefquinome frozen powder injection has high curative effect, accordingly, the injection times and the stress reactions of an animal can be reduced and the animal welfare can be improved. Moreover, the invention is more applicable for industrialization production.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a cefquinol sulfate freeze-dried powder injection and a preparation method thereof. technical background [0002] Cefquinol sulfate (also known as: cefquinome sulfate or cefquinome sulfate) (English name: Cefquinome sulfate) is a fourth-generation cephalosporin antibiotic for animals, with strong antibacterial activity, excellent pharmacokinetic characteristics, Small toxic and side effects, low residue, has a broad-spectrum strong antibacterial effect on both Gram-positive bacteria and Gram-negative bacteria, mainly used for bacterial infections of cattle, pigs, poultry and other animals, such as hemolytic Martensil Bacillus, Marcellocida, Salmonella, Escherichia coli, Streptococcus, Staphylococcus aureus, Corynebacterium, Haemophilus somnus, Serratia marcescens, Actinomyces pyogenes, Klebsiella, Proteus, Citrobacter, Clostridium, Actinomyces lobar pneumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/546A61K47/40A61P31/04
Inventor 万荣峰彭麟蔡冬江善祥季辉张军忍施宗傲
Owner JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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