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Medicinal composition for treating diabetes and obesity

A composition, obesity technology, applied in the direction of drug combination, metabolic disease, pharmaceutical formulation, etc.

Inactive Publication Date: 2012-02-29
郑飞雄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the current prior art has a combination of adding blood lipid-lowering drugs to hypoglycemic drugs, this combination is mainly due to the hyperlipidemia complications caused by hyperglycemia.

Method used

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  • Medicinal composition for treating diabetes and obesity
  • Medicinal composition for treating diabetes and obesity
  • Medicinal composition for treating diabetes and obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Sitagliptin phosphate (calculated as sitagliptin) 25g, simvastatin 5g;

[0065] Preparation method: Prepare 1000 tablets with the above-mentioned active ingredients according to the conventional method.

Embodiment 2

[0067] Sitagliptin phosphate 25g (calculated as sitagliptin), simvastatin 25g;

[0068] Preparation method: prepare 1000 capsules with the above active ingredients.

Embodiment 3

[0070] Sitagliptin phosphate 50g (calculated as sitagliptin), simvastatin 5g;

[0071] Preparation method: Prepare 1000 dispersible tablets according to the conventional method with the above active ingredients.

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PUM

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Abstract

The invention belongs to the technical field of medicinal preparations and particularly relates to a medicinal composition for treating diabetes and obesity and preparation and use thereof. The invention is characterized in that the active ingredient of a single dose of medicine comprises 10 to 90 milligrams of Sitagliptin or salt thereof based on Sitagliptin and 5 to 50 milligrams of Simvastatin or Lovastatin, preferably 25 to 50 milligrams of Sitagliptin or salt thereof and 5 to 25 milligrams of Simvastatin or Lovastatin. The medicinal composition can be prepared into any formulation acceptable in pharmaceutics, preferably oral solid preparation.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a pharmaceutical composition for treating diabetes and obesity, the active ingredients of which are sitagliptin and simvastatin / lovastatin. Background technique [0002] Sitagliptin, alias (3R)-3-amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[ 4,3-a]pyrazin-7-yl]-4-(2,-trifluorophenyl)butan-1-one, clinically used for type 2 diabetes. This drug is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which controls blood sugar levels by protecting endogenous incretins and enhancing their effects. Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), are incretins released in response to dietary intake. GLP-1 and GIP can increase insulin synthesis and release from pancreatic β cells through intracellular signaling pathways. GLP-1 can also reduce the secretion of glucagon from pancreatic α cells and reduce hepatic glucose production. However,...

Claims

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Application Information

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IPC IPC(8): A61K31/4985A61K31/366A61P3/10A61P3/04
Inventor 郑飞雄
Owner 郑飞雄
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