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Sodium gualenate aqueous solution

A technology of sodium azulene sulfonate and aqueous solution, which is applied in the fields of anhydride/acid/halide active ingredients, drug delivery, cosmetic preparations, etc. It can solve the problems of low solubility, difficulty in manufacturers, and lack of raw materials, etc., and achieve the effect of simple preparation

Active Publication Date: 2013-09-18
天津顶硕药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commercial products of sodium azulene sulfonate are mainly sodium azulene sulfonate powder products. When using it, it is directly added to paste products and liquid products. Additional dissolving equipment is required, and its microbial indicators must be guaranteed at the same time. Manufacturers bring certain difficulties, which is not conducive to popularization and use
[0004] However, sodium azulene sulfonate generally has low solubility in water, and its aqueous solution is easily contaminated by microorganisms. The directly prepared aqueous solution cannot be stored for a long time and cannot be used as a raw material.

Method used

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  • Sodium gualenate aqueous solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 (taking the preparation of 100kg as an example)

[0017] Sodium azulene sulfonate 0.45kg

[0018] Sterile purified water 99.5kg

[0019] Total: 100kg

[0020] In a 100,000-level purification workshop, weigh 0.45 kg of sodium azulene sulfonate, add 5 kg of purified water, heat to boiling, then add 94.5 kg of purified water at room temperature after heat sterilization, and stir evenly to obtain a semi-finished product of sodium azulene sulfonate aqueous solution. After the three indicators of sodium azulene sulfonate content, pH value, and total number of microorganisms pass the inspection, it can be packaged in a sterilized and dry-controlled packaging barrel to obtain a finished product of sodium azulene sulfonate aqueous solution (SGS-100).

Embodiment 2

[0021] Embodiment 2 (taking the preparation of 100kg as an example)

[0022] Sodium azulene sulfonate 0.55kg

[0023] Sterile purified water 99.45kg

[0024] Total: 100kg

[0025] In a 100,000-level purification workshop, weigh 0.55 kg of sodium azulene sulfonate, add 5 kg of purified water, heat to boiling, then add 94.45 kg of purified water at room temperature after heat sterilization, and stir evenly to obtain a semi-finished product of sodium azulene sulfonate aqueous solution. After the three indicators of sodium azulene sulfonate content, pH value, and total number of microorganisms pass the inspection, it can be packaged in a sterilized and dry-controlled packaging barrel to obtain a finished product of sodium azulene sulfonate aqueous solution (SGS-100).

Embodiment 3

[0026] Embodiment 3 (taking the preparation of 100kg as an example)

[0027]

[0028] In the purification workshop, utensils and equipment are sterilized with 75% ethanol before use. First weigh 60,0.3kg of polyoxyethylene hardened castor oil, dissolve it into 98.185kg of purified water sterilized by ultraviolet rays, stir evenly, then add 800.5kg of Tween, stir well, then add 0.005kg of sodium bicarbonate, add cation Surfactant 0.1kg, finally add sodium azulene sulfonate 1kg, stir for 30 minutes to dissolve completely, obtain the semi-finished product of aqueous solution of sodium azulene sulfonate, after the three indicators of sodium azulene sulfonate content, pH value, and total number of microorganisms are qualified, namely It can be packaged in a sterilized and dry-controlled packaging barrel to obtain the finished product of sodium azulene sulfonate aqueous solution (SGS-100).

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Abstract

The invention relates to a sodium gualenate aqueous solution, which comprises the following components: 0.45%-0.55% of sodium gualenate and 99.45%-99.55% of aseptic purified water, or comprises the following components by weight ratio: 0.55%-4% of sodium gualenate addition, 0.005%-1% of additive and 95%-99.45% of purified water. The additive comprises one or more of a cationic surfactant, chlorhexidine, 95% ethanol, dipotassium hydrogen phosphate, anhydrous sodium dihydrogen phosphate, trisodium phosphate, EDTA disodium, polyoxyethylene-hardened castor oil 60, polyvinylpyrrolidone K30, polyvinylpyrrolidone K90, tween -80, tween -60, amphoteric surfactant, sodium carbonate, sodium hydroxide, sodium bicarbonate and citric acid. The sodium gualenate aqueous solution is a liquid preparation which is conveniently produced and used in daily chemical product, cosmetic and health product industry, and solves the practical problem that the addition of the extra equipment investment is required when the sodium gualenate powder product is directly used during the practical production process in the daily chemical product, cosmetic, health product industry.

Description

technical field [0001] The present invention relates to a liquid preparation. In particular, it relates to an aqueous solution of sodium azulene sulfonate that can be conveniently produced and used in industries such as daily chemical products, cosmetics, and health care products. Background technique [0002] Sodium azulene sulfonate, also known as water-soluble azulene, is an active ingredient of the natural plant chamomile. Its chemical name is 1.4-dimethyl-7-isopropyl-3-sodium azulene sulfonate, and its general chemical formula is: C 15 h 17 NaO 3 S 1 / 2H 2 O, dark blue crystal or crystalline powder, odorless and tasteless. [0003] At present, the commercially available products of sodium azulene sulfonate are mainly sodium azulene sulfonate powder products. When using it, it is directly added to paste products and liquid products, and additional dissolving equipment is required. At the same time, its microbial indicators must be guaranteed, so give Manufacturer bri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/04A61K8/46A61K9/08A61K31/185
Inventor 许荧
Owner 天津顶硕药业股份有限公司
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