Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative in preparing medicine for treating heart cerebrovascular disease caused by vasoconstriction

Abstract

The invention discloses new medicinal application of derivatives of flavanone compound farrerol, a pharmaceutically-acceptable salt of the flavanone compound farrerol and farrerol and the pharmaceutically-acceptable salts of the derivatives, particularly application to preparation of a medicine for treating heart cerebrovascular disease caused by vasoconstriction. Through the experiment of an isolated rat aortic vascular ring, the derivatives and the pharmaceutically-acceptable salts thereof have obvious vasodilation effects and simultaneously have the characteristics of low toxicity, small side effect and the like, can be industrially synthesized, are low in price, and can be matched with the pharmaceutically-acceptable medicinal auxiliary materials for use to be prepared into common preparations such as injection, tablets, pills or capsules and the like which can be clinically used for preventing and controlling heart cerebrovascular disease caused by vasoconstriction, so that new methods and means are provided for clinical treatment of heart cerebrovascular disease.

Description

technical field [0001] The invention belongs to the field of new uses of natural compounds, specifically the dihydroflavonoid compound rhododendron and its pharmaceutically acceptable salts, three derivatives of rhododendron and their pharmaceutically acceptable salts in the preparation of drugs for cardiovascular and cerebrovascular diseases caused by vasoconstriction in the application. Background technique [0002] At present, the research on drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases is a research hotspot in the field of drug research, and the types of single antihypertensive drugs are very rich, such as diuretics, β receptor blockers, calcium antagonists, angiotensin converting enzyme inhibitors and Angiotensin receptor antagonists, etc. Although the research on the above drugs is relatively mature and widely used in clinical practice, the drugs have relatively large side effects and many adverse reactions after long-term use,...

AI Technical Summary

Problems solved by technology

[0005] There are no relevant reports at home and abroad on the pharmacological effects of DJS-1 on the prevention and treatment of cardiovascular and cerebrovascular diseases caused by vasoconstriction.

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