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Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative to medicine for treating heart cerebrovascular disease caused by vasoconstriction

A cardiovascular and cerebrovascular disease, vasoconstriction technology, applied in cardiovascular system diseases, drug combinations, medical preparations containing active ingredients, etc. , the effect of low price

Inactive Publication Date: 2012-03-28
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are no relevant reports at home and abroad on the pharmacological effects of DJS-1 on the prevention and treatment of cardiovascular and cerebrovascular diseases caused by vasoconstriction.

Method used

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  • Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative to medicine for treating heart cerebrovascular disease caused by vasoconstriction
  • Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative to medicine for treating heart cerebrovascular disease caused by vasoconstriction
  • Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative to medicine for treating heart cerebrovascular disease caused by vasoconstriction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] 1. Dihydroflavonoid novel compound (DJS-X) relaxes the isolated aortic ring in rats

[0032] 1.1 Experimental animals

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PUM

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Abstract

The invention discloses new medicinal application of derivatives of flavanone compound farrerol, a pharmaceutically-acceptable salt of the flavanone compound farrerol and farrerol and the pharmaceutically-acceptable salts of the derivatives, particularly application to preparation of a medicine for treating heart cerebrovascular disease caused by vasoconstriction. Through the experiment of an isolated rat aortic vascular ring, the derivatives and the pharmaceutically-acceptable salts thereof have obvious vasodilation effects and simultaneously have the characteristics of low toxicity, small side effect and the like, can be industrially synthesized, are low in price, and can be matched with the pharmaceutically-acceptable medicinal auxiliary materials for use to be prepared into common preparations such as injection, tablets, pills or capsules and the like which can be clinically used for preventing and controlling heart cerebrovascular disease caused by vasoconstriction, so that new methods and means are provided for clinical treatment of heart cerebrovascular disease.

Description

Technical field [0001] Background technique [0002] [0003] 2 [0004] [0005] Invention content [0006] As well as As well as Essence [0007] [0008] To. [0009] [0010] [0011] [0012] [0013] [0014] [0015]Among them, the medicinal salt (DJS-2, DJS-3, DJS-4) of the medicinal salt (DJS-1) of the dihydroflavonoids (DJS-1) of the dihydroflavonoids (DJS-1) of the medicinal salt (DJS-2, DJS-3, DJS-4) is the bookThe preparation methods are well known by the field of domains: separate compounds 5,7-dihydroxyl-2- (4′-hydroxylphenyl) -6,8-dihydrogen benzene and dihydrous pyra-4-ketone(DJS-1); 5,7-dihydroxyl-2- (2′-nitrate phenyl) -6,8-dihydrogen pyrine pyra-4-ketone (DJS-2); 2-(Fu Fu-2-Bidth) -5,7-two-hydroxyl-6,8-dihydrogen pyrine pyra-4-ketone (DJS-3) and 5,7-dihydroxyl-2- (2 ′, 4'-dichlorophenyl) -6,8-dihydrophoherene-4-ketone (DJS-4), add an appropriate amount of alkaline solution (such as NaOH, KOH solution), and after fully reacting, Extract, add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/08
Inventor 李青山秦小江韩玲革侯晓敏班树荣石磊
Owner SHANXI MEDICAL UNIV
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