Method for preparing high-purity magnolol and magnolol

A technology of honokiol and magnolol, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of loss of honokiol and honokiol, corrosion of equipment, difficulty in popularization, etc. Achieve the effect of simple equipment, large processing capacity and favorable follow-up processing

Inactive Publication Date: 2013-10-30
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of the above-mentioned methods use chemical reactions, and some use adsorbents to easily make magnolol and honokiol loss and corrode equipment; some required equipment costs are higher and are not easy to popularize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 400g of Magnolia officinalis bark powder, extract four times at 55°C, add 2400ml of petroleum ether for extraction for 1.5 hours each time, combine the four extracts and concentrate under reduced pressure to obtain extract 19.23, add 200mL of ethanol solution to the extract, and then add 100Lm A large amount of precipitation was produced in water, filtered, and the filtrate was concentrated under reduced pressure to obtain 9.7g of extract, left to stand overnight, dissolved and filtered with petroleum ether to obtain 1.87g of magnolol crude crystals, the filtrate was added with an equal volume of ethanol aqueous solution to extract the petroleum ether solution 4 times , concentrate the aqueous ethanol until solids are precipitated, then add petroleum ether to dissolve and filter to obtain 2.7 g of honokiol crude crystals; add an equal volume of aqueous ethanol to extract the petroleum ether solution for 5 times, then concentrate the aqueous ethanol until solids are ...

Embodiment 2

[0031] Weigh 400g of Magnolia officinalis bark powder, extract four times at 60°C, add 2400ml of cyclohexane for extraction for 1 hour each time, combine the four extracts and concentrate under reduced pressure to obtain 20.94g of extract, add 300mL of ethanol solution to the extract, Add 150Lm of water to produce a large amount of precipitation, filter, and concentrate the filtrate under reduced pressure to obtain 9.37g of extract, let stand overnight, add petroleum ether to dissolve and filter to obtain 2.3g of magnolol crude crystals, add an equal volume of ethanol aqueous solution to the filtrate to extract petroleum ether solution 4 times, concentrate the aqueous ethanol solution until solids are precipitated, then add petroleum ether to dissolve and filter to obtain 3.0 g of honokiol crude crystals; add an equal volume of aqueous ethanol to extract the petroleum ether solution 5 times, then concentrate the aqueous ethanol solution until there are solids Precipitate, then ...

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Abstract

The invention discloses a method for preparing high-purity magnolol and magnolol. The method comprises the following steps: preparing a Magnolia officinalis bark extract by use of a weakly polar solvent under heating condition, concentrating the extract, and adopting an ethanol water precipitation method to remove partial impurities; filtering, concentrating the filtrate under reduced pressure to obtain magnolol and magnolol extractum; standing the extractum to separate out the precipitate, dissolving with a small amount of petroleum ether, filtering, washing with petroleum ether, and precipitating to obtain a solid material which is crude magnolol; and then performing selective extraction with a solvent to separately obtain magnolol and crude magnolol, and recrystallizing the crude magnolol to obtain high-purity magnolol and magnolol respectively. The technology of the method has the advantages of fewer production steps, simple equipment and operation method, short production cycle and high product yield and purity; and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method, in particular to a method for preparing high-purity magnolol and honokiol. technical background [0002] Magnolia officinalis is a traditional Chinese herbal medicine in our country, and it is also a precious tree species unique to our country. It is a national II key protected wild plant and is currently widely planted. Magnolol and honokiol are the main active ingredients in Magnolia officinalis, which have antibacterial [1-3] , anti-inflammatory [4-5] ,Antitumor [6-8] , anticoagulant [9] , inhibit muscle contraction [10] , liver protection and antioxidant [11] , neuroprotection [12-13] and other pharmacological effects. Magnolol and honokiol are isomers, and they have both common effects and their own characteristics in terms of pharmacological effects. Magnolol inhibits muscle contraction more rapidly than honokiol [10] , while anti-anxiety [14] , neuroprotection [12] The main effect is hono...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/70
Inventor 韦万兴苏德辉周敏凌秀荣
Owner GUANGXI UNIV
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