Medical modified glucan coated magnetic nanometer particle composite material and preparation method thereof

A technology of magnetic nanoparticles and composite materials, which is applied in the field of medical modified dextran-coated magnetic nanoparticle composite materials and its preparation, and can solve the problems that nanoparticles cannot be dispersed for biological applications, surface modification methods are complicated, and reagents are expensive. , to achieve the effect of low synthesis cost, strong hydrophilicity and excellent biocompatibility

Inactive Publication Date: 2012-12-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In recent years, there have been quite a few reports on the synthesis and surface modification of Fe3O4 nanoparticles and series of ferrite particles (Sophie Laurent. Chemical Review, 2010, 108, 2064-2110), various synthesis methods (such as large latex method, sol- Gel method, precursor hydrolysis or thermal decomposition method, flow injection synthesis method, electrospray synthesis method, etc.) and the use of various surfactants have solved many difficult problems in application to a certain extent, the most important of which is Oleic acid or oleylamine is a synthetic method for high-temperature pyrolysis of surfactants, but the resulting nanoparticles cannot be dispersed in water, which limits their biological applications
Therefore, these oil-soluble nanoparticles have to undergo a series of surface modifications to obtain water solubility and biocompatibility, and most of these surface modification methods are more complicated and the reagents are more expensive

Method used

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  • Medical modified glucan coated magnetic nanometer particle composite material and preparation method thereof
  • Medical modified glucan coated magnetic nanometer particle composite material and preparation method thereof
  • Medical modified glucan coated magnetic nanometer particle composite material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Synthesis of modified dextran-coated ferroferric oxide magnetic nanoparticle composites:

[0035] a. Add 0.5g of dextran with a molecular weight of 40,000 to 10ml of deionized water, stir and heat to 50°C to dissolve completely;

[0036] b. Add 0.4g NaIO 4 The solid powder was dissolved in 7.5ml deionized water, and NaIO 4 After completely dissolving, pour it into the dextran solution prepared in step a, stir and mix, and maintain the solution at 85°C for 30 minutes. The solution turns from colorless to reddish brown, and finally light yellow. At this time, stop heating and add 5ml of ethylene glycol. Adjust the pH to 7 with NaOH;

[0037] c. Add 0.27g FeCl 3 ·6H 2 O and 0.784g Fe(NH 4 ) 2 (SO 4 ) 2 ·6H 2 O was added to 10ml of deionized water, then mixed with the solution obtained in step b and transferred to the reaction kettle, and stirred for half a minute;

[0038] d. Dissolve 0.6g NaOH in 5ml deionized water, quickly add to the above reaction kettle solu...

Embodiment 2

[0041] Modified dextran coated MnFe 2 o 4 Synthesis of magnetic nanoparticle composites:

[0042] a. Add 0.5g of dextran with a molecular weight of 40,000 to 10ml of deionized water, stir and heat to 50°C to dissolve completely;

[0043] b. Add 0.4g NaIO 4 The solid powder was dissolved in 7.5ml deionized water, and NaIO 4 After completely dissolving, add to the dextran solution prepared in step a, stir, and keep the solution at 85°C for 30 minutes. The solution turns from colorless to reddish brown, and finally light yellow. At this time, stop heating and add 5ml of ethylene glycol. Adjust the pH to 7;

[0044] c. Add 0.27g FeCl 3 ·6H 2 O, 0.397g Fe(NH 4 ) 2 (SO 4 ) 2 ·6H 2 O and 0.198g MnCl 2 4H 2 O, dissolved in 10ml deionized water, then mixed with the solution obtained in step b and transferred to the reaction kettle, stirred for half a minute;

[0045] d. Dissolve 0.6g NaOH in 5ml deionized water, quickly add to the above reaction kettle solution, and conti...

Embodiment 3

[0047] Modified dextran coated ZnFe 2 o 4 Synthesis of magnetic nanoparticle composites:

[0048] a. Add 0.5g of dextran with a molecular weight of 40,000 to 10ml of deionized water, stir and heat to 50°C to dissolve completely;

[0049] b. Add 0.4g NaIO 4 The solid powder was dissolved in 7.5ml deionized water, and NaIO 4 After completely dissolving, add to the dextran solution prepared in step a, stir, and keep the solution at 85°C for 30 minutes. The solution turns from colorless to reddish brown, and finally light yellow. At this time, stop heating and add 5ml of ethylene glycol. Adjust the pH to 7;

[0050] c. Add 0.27g FeCl 3 ·6H 2 O, 0.397g Fe(NH 4 ) 2 (SO 4 ) 2 ·6H 2 O and 0.136 g ZnCl 2 Dissolve in 10ml deionized water, then mix with the solution obtained in step b and transfer to the reaction kettle, stir for half a minute;

[0051] d. Dissolve 0.6g NaOH in 5ml deionized water, quickly add to the above reaction kettle solution, and continue to stir for 1...

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Abstract

The invention discloses a medical modified glucan coated magnetic nanometer particle composite material and a preparation method thereof, which belong to the technical field of biomedicine application type inorganic advanced nanometer material preparation processes. In the method, a reaction process is carried out under the solvent thermal condition, a series of ferrate nanometer particles and high-hydrophily and high-biocompatibility ferroferric oxide capable of being used for antibody and cell separation as well as medical nuclear magnetic resonance imaging comparing agents are obtained through preparation, the obtained particles have good stability in water, high-concentration colloid can not be precipitated at least within 5 months, in addition, the particle diameter distribution of the nanometer particles is uniform, and the synthesis cost is relatively low.

Description

technical field [0001] The invention belongs to the technical field of biomedical application inorganic advanced nanometer material preparation technology, and in particular relates to a medical modified glucan-coated magnetic nanoparticle composite material and a preparation method thereof. technical background [0002] When the particles of ferromagnetic substances are smaller than the critical size, the magnetic orientation force generated by the external field is not enough to resist the interference of thermal disturbance, and its magnetization properties are similar to those of paramagnets, which is called superparamagnetism. The critical size is related to temperature. For example, the critical radius of spherical iron particles is 12.5 nanometers at room temperature, but it is ferromagnetic at 4.2K with a radius of 2.2 nanometers. The magnetization curve of superparamagnets is different from that of ferromagnets, and there is no hysteresis. When the external magneti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/20A61K49/18A61K49/12
Inventor 汪乐余黄盛
Owner BEIJING UNIV OF CHEM TECH
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