Targeting polypeptide SPSCVLP capable of inhibiting growth and transfer of liver cancer and application thereof

A technology for inhibiting liver cancer and liver cancer, which can be used in peptides, drug combinations, anti-tumor drugs, etc.

Inactive Publication Date: 2012-05-02
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, peptides are easily degraded in vivo and have a short half-life, which leads to the inability of peptides targeting tumor cells to produce significant tumor inhibitory effects.

Method used

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  • Targeting polypeptide SPSCVLP capable of inhibiting growth and transfer of liver cancer and application thereof
  • Targeting polypeptide SPSCVLP capable of inhibiting growth and transfer of liver cancer and application thereof
  • Targeting polypeptide SPSCVLP capable of inhibiting growth and transfer of liver cancer and application thereof

Examples

Experimental program
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Effect test

Embodiment

[0025] (1) Using magnetic bead sorting technology, CD105 magnetic beads were used to sort liver cancer vascular endothelial cells (TEC) and normal liver tissue vascular endothelial cells (NEC), and the biological characteristics of the two were identified, and it was found that TEC and There are many biological differences in NEC. Such as Figure 1~3 As shown, compared with NEC, TEC has stronger angiogenesis, proliferation and motility, and adhesion ability, as shown in Figure 4~6 As shown, TECs are more resistant to anti-angiogenic targeted drugs as well as chemotherapeutic drugs.

[0026] (2) Screen random phage peptide library by BRASIL method: first, random phage peptide library is co-incubated with NEC, the new phage peptide library obtained in this way eliminates non-specific phage bound to NEC cell surface, and then screens for TEC cell surface bound phage. Since TEC and the corresponding NEC have similar genetic backgrounds, the inherent trait differences of differ...

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Abstract

The invention provides a polypeptide for targeting a liver cancer vascular endothelial cell and application thereof. The polypeptide is characterized by comprising an amino acid sequence of SPSCALP. The polypeptide SPSCALP provided by the invention can target the liver cancer vascular endothelial cell, is used for mainly inhibiting a PI3K-AKT signal path of the liver cancer vascular endothelial cell and inhibiting the biological function of the liver cancer vascular endothelial cell, but has no remarkable influence on normal liver tissue endothelial cells.

Description

technical field [0001] The invention relates to a targeting polypeptide SPSCVLP capable of inhibiting the growth and metastasis of liver cancer. Background technique [0002] Hepatocellular carcinoma (liver cancer for short) is one of the most common and most malignant tumors in the world, ranking the sixth in the incidence of malignant tumors and the third in the cause of death in the world, and has become the second cause of death in malignant tumors in my country . Although the basic research and diagnosis and treatment of liver cancer have made significant progress in recent decades, the overall prognosis of liver cancer is still poor and has not been significantly improved, and the 5-year survival rate is only about 5%. The curative treatment is surgical resection, but most liver cancers are diagnosed at an advanced stage for the first time, and only 10% of liver cancer patients are suitable for surgical treatment. Even after surgical resection, there is still a recurr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61P35/00
Inventor 张巨波孙惠川任正刚徐泱张博恒樊嘉汤钊猷
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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