Targeting polypeptide SPSCVLP capable of inhibiting growth and transfer of liver cancer and application thereof

A technology for inhibiting liver cancer and liver cancer, which can be used in peptides, drug combinations, anti-tumor drugs, etc.
CN102432671AInactive Publication Date: 2012-05-02ZHONGSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONGSHAN HOSPITAL FUDAN UNIV
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a polypeptide for targeting a liver cancer vascular endothelial cell and application thereof. The polypeptide is characterized by comprising an amino acid sequence of SPSCALP. The polypeptide SPSCALP provided by the invention can target the liver cancer vascular endothelial cell, is used for mainly inhibiting a PI3K-AKT signal path of the liver cancer vascular endothelial cell and inhibiting the biological function of the liver cancer vascular endothelial cell, but has no remarkable influence on normal liver tissue endothelial cells.
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Description

technical field

[0001] The invention relates to a targeting polypeptide SPSCVLP capable of inhibiting the growth and metastasis of liver cancer. Background technique

[0002] Hepatocellular carcinoma (liver cancer for short) is one of the most common and most malignant tumors in the world, ranking the sixth in the incidence of malignant tumors and the third in the cause of death in the world, and has become the second cause of death in malignant tumors in my country . Although the basic research and diagnosis and treatment of liver cancer have made significant progress in recent decades, the overall prognosis of liver cancer is still poor and has not been significantly improved, and the 5-year survival rate is only about 5%. The curative treatment is surgical resection, but most liver cancers are diagnosed at an advanced stage for the first time, and only 10% of liver cancer patients are suitable for surgical treatment. Even after surgical resection, there is still a recurr...

Claims

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