Biodegradable temperature response hydrogel and preparation method thereof

A temperature-responsive, biodegradable technology, applied in the direction of medical preparations and pharmaceutical formulations of non-active ingredients, can solve the problems of non-biodegradable, limited application, low LCST, etc., achieve good biodegradability, broad application prospects, The effect of fast response speed
CN102432774BInactive Publication Date: 2013-03-20GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
Publication Date
2013-03-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses biodegradable temperature response hydrogel and a preparation method thereof. The method comprises the following steps of: (1) reacting terminal hydroxyl group of polycaprolactone dihydric alcohol with crylic acid (or methacrylic acid) to prepare polycaprolactone macromolecule cross-linking agent; (2) reacting singe terminal hydroxyl group of polyethylene glycol monomethyl ether and acryloyl chloride (or methacryloylchloride) to prepare a polyethylene glycol monomethyl ether macromolecule monomer; and (3) copolymerizing the polycaprolactone macromolecule cross-linking agent, the polyethylene glycol monomethyl ether macromolecule monomer and N-isopropylamide according to a certain ratio to obtain the biodegradable temperature response hydrogel. Compared with the traditional hydrogel, the hydrogel disclosed by the invention has the advantages of being rapid in response speed, good in mechanical strength, biodegradable and good in biocompatibility; therefore, the hydrogel is hopeful to be applied in the drug slow release field.
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Description

technical field

[0001] The invention belongs to the field of functional materials, and in particular relates to a hydrogel which can be used for drug release, in particular to an N-isopropylacrylamide-based and biodegradable temperature-responsive hydrogel and a preparation method thereof. Background technique

[0002] The drug release drug delivery system is a type of preparation or device that releases the drug at a predetermined time and at a certain rate in the acting organ or specific target tissue through physical and chemical methods, and maintains the drug concentration within an effective concentration for a long time . Drug controlled release generally uses polymers as drug carriers or media to make certain dosage forms, so as to control the drug release rate in the human body, so that the drug can be released in the body at a certain rate within the required time range according to the designed dose. Slow release to achieve the purpose of high-efficiency treatmen...

Claims

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